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ADAM12 — NOTCH1
Text-mined interactions from Literome
Huovila et al., Trends Biochem Sci 2005
:
The recent studies have also begun to elucidate the substrate specificity and the mechanisms that control
ADAM mediated shedding events that regulate, for example, growth-factor and
Notch signalling, and the processing of the amyloid precursor protein
Dyczynska et al., J Biol Chem 2007
:
Our findings expand the
role of
ADAM proteins in the regulation of
Notch signaling
Zolkiewska et al., Cell Mol Life Sci 2008
:
ADAM mediated cleavage of
Notch represents the first step in regulated intramembrane proteolysis of the receptor, leading to activation of the Notch pathway
Li et al., J Biol Chem 2011
:
Metalloprotease-disintegrin
ADAM12 expression is
regulated by
Notch signaling via microRNA-29 ... We report here that
ADAM12 expression in cultured mammalian cells is
up-regulated by
Notch signals ... Expression of a constitutively active form of
Notch1 in murine fibroblasts, myoblasts, or mammary epithelial cells or activation of the endogenous Notch signaling by co-culture with ligand expressing cells
increases ADAM12 protein and mRNA levels ...
Up-regulation of
ADAM12 expression by
Notch requires new transcription, is activated in a CSL dependent manner, and is abolished upon inhibition of I?B kinase ... We further show that the microRNA-29 family, which has a predicted conserved site in the 3'-untranslated region of mouse Adam12, plays a critical role in mediating the stimulatory
effect of
Notch on
ADAM12 expression