◀ Back to EPHA1
EFNA5 — EPHA1
Pathways - manually collected, often from reviews:
-
KEGG Axon guidance:
EFNA1/EFNA2/EFNA3/EFNA4/EFNA5
→
EPHA1/EPHA2/EPHA3/EPHA4/EPHA5/EPHA6/EPHA7/EPHA8
(protein-protein, activation)
-
Reactome Reaction:
EFNA5
→
EPHA1
(reaction)
Marignani et al., J Cell Biol 2001, Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005, Himanen et al., Curr Opin Cell Biol 2007, Himanen et al., EMBO Rep 2009
-
Reactome Reaction:
EFNA5
→
EPHA1
(indirect_complex)
-
Reactome Reaction:
EFNA5
→
EPHA1
(direct_complex)
Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Himanen et al., Curr Opin Cell Biol 2007, Himanen et al., EMBO Rep 2009
Text-mined interactions from Literome
Nie et al., Nat Neurosci 2010
:
We also found that
EphA receptor
activation by
ephrin-A ligands in neurons led to inhibition of extracellular signal regulated kinase 1/2 ( ERK1/2 ) activity and decreased inhibition of Tsc2 by ERK1/2
Bi et al., J Neurophysiol 2011
:
These results suggest that these factors can be categorized differently, with the contact mediated
activation of
EphA receptors by
ephrin-A5 overriding the diffusion mediated effect of BDNF
Petty et al., PloS one 2012
(Neoplasm Metastasis...) :
During tumor progression,
EphA2 receptor can gain ligand independent pro-oncogenic functions due to Akt activation and
reduced ephrin-A ligand engagement