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PIK3CA — VAV1

Pathways - manually collected, often from reviews:

• BioCarta t cell receptor signaling pathway: PI3K complex (PIK3CA-PIK3R1) → Vav (VAV1) (modification, activates)
• KEGG Focal adhesion: PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 → VAV1/VAV2/VAV3 (protein-protein, compound)
• KEGG Natural killer cell mediated cytotoxicity: PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 → VAV1/VAV2/VAV3 (enzyme-enzyme, compound)
• KEGG Regulation of actin cytoskeleton: TIAM1/TIAM2/VAV1/VAV2/VAV3 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, compound)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: VAV1 (VAV1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Manetz et al., Mol Cell Biol 2001, Barker et al., Mol Biol Cell 1995
  Evidence: assay, other species

Text-mined interactions from Literome

Bertagnolo et al., Cell Signal 2004 : The Vav/p85 interaction is essential for the ATRA induced PI 3-K activity and for association of PI 3-K with actin, particularly in the nucleus
Bertagnolo et al., Exp Cell Res 2005 (Leukemia, Promyelocytic, Acute) : We have previously demonstrated that the amount and the tyrosine phosphorylation of Vav are up-regulated in both whole cells and nuclei of tumoral promyelocytes induced to granulocytic maturation by ATRA and that tyrosine phosphorylated Vav does not display any ATRA induced GEF activity but contributes to the regulation of PI 3-K activity
Vigorito et al., Cell Signal 2006 : These findings show that Vav proteins and PI3K regulation of PLCgamma contributes to the activation of PKD in response to BCR and or CD19 cross linking