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MYLK — RELA

Text-mined interactions from Literome

Wadgaonkar et al., J Cell Biochem 2005 : Endothelial cell myosin light chain kinase (MLCK) regulates TNFalpha induced NFkappaB activity ... Both TNFalpha induced increase in NFkappaB dependent transactivation measured by NFkappaB luciferase reporter assay ( approximately fivefold ) and nuclear translocation of NFkappaB were significantly inhibited by MLCK-selective inhibitors, KT5926 ( 60 % inhibition of luciferase activity ) and ML7 ( 50 % decrease ) ... Furthermore, our data revealed that inhibition of MLCK attenuated the TNFalpha induced IkappaB phosphorylation, translocation of p65, NFkappaB-DNA binding, and NFkappaB transcriptional activity
Ye et al., Am J Physiol Gastrointest Liver Physiol 2006 : The TNF-alpha induced increase in MLCK promoter activity was mediated by NF-kappaB activation, and the inhibition of NF-kappaB activation prevented the TNF-alpha induced increase in promoter activity and the subsequent increase in MLCK protein expression and Caco-2 TJ permeability ... NF-kappaB p50/p65 activation of the MLCK promoter then leads to a stepwise increase in MLCK transcription, expression and activity, and MLCK mediated opening of the intestinal TJ barrier
Ye et al., J Cell Mol Med 2008 : TNF-alpha induced increase in MLCK promoter activity was mediated by NF-kappaB activation
Al-Sadi et al., J Immunol 2008 : The IL-1beta induced increase in MLCK mRNA transcription and subsequent increase in MLCK protein expression and Caco-2 TJ permeability was mediated by activation of NF-kappaB ... Our findings also indicate that the IL-1beta induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an NF-kappaB dependent increase in MLCK gene transcription
Suzuki et al., J Immunol 1994 : NF-kappa B activation induced by okadaic acid or calyculin A was not blocked by a myosin light chain kinase inhibitor, but was prevented by a protease inhibitor ... These results suggest that 1 ) phosphatase inhibitors either target a component of signal transduction, which occurs downstream to an antioxidant-sensitive step or use distinct signaling pathways ; 2 ) inhibition of phosphatases 1 and 2A is not a step in the pathway of TNF-alpha-, lymphotoxin-, or PMA induced NF-kappa B activation ; 3 ) myosin light chain kinase does not participate in NF-kappa B activation ; and 4 ) activation of NF-kappa B by phosphatase inhibitors is controlled by proteases