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JAK2 — NFKB1
Text-mined interactions from Literome
Nomura et al., Toxicol Lett 1998
(Ischemic Attack, Transient) :
LPS caused intranuclear translocation of
NF-kappaB , and IFNgamma
induced phosphorylation of
Jak2 and Stat1, followed by the translocation of Stat1 into the nucleus
Carvalho et al., Oncogene 2005
(Carcinoma, Renal Cell...) :
Inhibition of
JAK2 , one of the receptor-proximal elements of EPO mediated signal transduction, greatly
diminished the EPO mediated chemosensitization and
NF-kappaB inhibition
Nefedova et al., J Immunol 2005
:
Inhibition of
Jak2/STAT3 signaling
resulted in activation of the transcription factor
NF-kappaB
Kanda et al., Endocrinology 2007
(MAP Kinase Signaling System...) :
Inhibitors of
Janus kinase ( JAK ) , p38 MAPK, and MAPK/ERK kinase (MEK)
suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and
NF-kappaB , STAT1, and IRF-1 activities
Hu et al., J Leukoc Biol 2007
:
Similarly, basal ITAM signaling augments IFN signaling and function of receptor activator of
NF-kappaB , but extensive ITAM activation
inhibits Jak-STAT signaling
Huang et al., J Immunol 2007
:
Requirement for both
JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent
NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Jones et al., Journal of inflammation (London, England) 2007
:
Here, we examine the
role of protein kinase C isoforms and
janus activated kinase 2 (JAK2) activation in
NF-kappaB activation and LPS stimulated NO production
Pincheira et al., J Immunol 2008
:
TNFR1/c-Src, but not
TNFR1/Jak2 ,
plays an obligate role in the activation of
NF-kappaB by TNF, whereas TNFR1/Jak2, but not TNFR1/c-Src, plays an obligate role in the activation of STAT3
Marrero et al., Brain Res 2009
(Inflammation) :
Convergence of alpha 7 nicotinic acetylcholine receptor activated pathways for anti-apoptosis and anti-inflammation : central role for
JAK2 activation of STAT3 and
NF-kappaB
Qi et al., J Cell Physiol 2009
:
IFN-gamma potentiates TNF-alpha induced CXCL10 production in THP-1 cells by increasing the
activation of STAT1 and
NF-kappaB through JAK1 and
JAK2
Peña et al., J Mol Med (Berl) 2010
(Sepsis) :
JAK2 inhibitor
prevents the activation of the canonical p65RelA/p50NF-kappaB1 pathway but not the other
NF-kappaB proteins