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HSPB1 — PGF

Text-mined interactions from Literome

Kozawa et al., J Cell Biochem 1999 : In this study, we investigated the effect of PGF ( 2alpha ) on the induction of heat shock protein 27 (HSP27) , a low-molecular-weight heat shock protein, in these cells ... PGF ( 2alpha ) significantly induced the accumulation of HSP27 dose-dependently within the range of 10 nM to 10 microM ... HSP27 induction by PGF ( 2alpha ) was reduced by U-73122, a phospholipase C inhibitor, or propranolol, a phosphatidic acid phosphohydrolase inhibitor ... These results indicate that PGF ( 2alpha ) stimulates the induction of HSP27 via p42/p44 MAP kinase activation, which depends on upstream PKC activation in osteoblasts
Knock et al., Am J Physiol Lung Cell Mol Physiol 2005 (Anoxia...) : Western blot analysis revealed that PGF ( 2alpha ) ( 20 microM ) increased phosphorylation of p38 MAPK and of heat shock protein 27 (HSP27) , and this was abolished by SB-203580 but not by SB-202474 ( both 2 microM )