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EPHB2 — PLA2G1B
Text-mined interactions from Literome
Bae et al., Mol Pharmacol 2003
(MAP Kinase Signaling System) :
We also found that
ERK mediated cytosolic
PLA2 activity is essential for superoxide generation
Chen et al., FEBS Lett 2005
(MAP Kinase Signaling System) :
GABA, progesterone and zona pellucida activation of
PLA2 and
regulation by
MEK-ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa ... Taken together, our results suggest that
PLA2 plays a fundamental role in agonist stimulated exocytosis and that
MEK-ERK1/2 are
involved in PLA2 regulation during this process
Xie et al., Cancer Biol Ther 2006
(Carcinoma, Hepatocellular...) :
Other
PLA(2) inhibitors such as the cytosolic and Ca ( 2+ ) -independent PLA(2) inhibitor methyl arachidonyl fluorophosphonate, and another sPLA ( 2 ) inhibitor, thioetheramide-phosphatidylcholine, only transiently
inhibited ERK1/2 phosphorylation and did not display the stimulatory effect
Menshikov et al., J Vasc Res 2006
:
Induction of MMP9 by uPA in THP-1 monocytes is via a pathway involving
MEK1-ERK1/2 mediated activation of cytosolic
PLA2 and eicosanoid generation
Khundmiri et al., American journal of physiology. Renal physiology 2008
:
Pharmacological inhibition of
PLA2 did not
prevent PTH stimulated
ERK phosphorylation but completely prevented PKCalpha translocation
Burkholder et al., Biochem Biophys Res Commun 2009
:
Stretch induced
ERK2 phosphorylation
requires PLA2 activity in skeletal myotubes ... The purpose of this study was to determine whether
PLA2 activation
contributes to stretch induced phosphorylation of
ERK2 in skeletal muscle myotubes ... Inhibition of
PLA2 prevented
ERK2 phosphorylation, while inhibition of prostaglandin or leukotriene synthesis did not ... It appears that
PLA2 , but not further metabolism of arachidonic acid, is
required for stretch induced activation of
ERK2 ... These results suggest that stretch induced activation of
ERK2 may
result from an interaction between
PLA2 derived lysophosphatidylcholine and membrane receptors
Li et al., Atherosclerosis 2013
:
ERK1/2 , JNK1/2, and p38 inhibition
reduced SAA induced
Lp-PLA2 production