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EPHB2 — LHCGR

Text-mined interactions from Literome

Shiraishi et al., Endocrinology 2006 : Because a dominant negative mutant of Shc inhibits the LHR mediated activation of Ras and the phosphorylation of ERK1/2 , we conclude that the LHR mediated phosphorylation of ERK1/2 is mediated, at least partially, by the classical pathway used by growth factor receptors ... We conclude that the SFKs are responsible for the LHR mediated phosphorylation of the EGFR and Shc, the formation of complexes containing Shc and Sos, the activation of Ras, and the phosphorylation of ERK1/2
Shiraishi et al., Exp Cell Res 2008 : Transfection of interfering constructs shows that the LHR mediated activation of Fyn in MA-10 cells is necessary for the phosphorylation of the EGFR and ERK1/2 in I-10 cells
Tai et al., Mol Endocrinol 2011 : Activation of the LH receptor (LHR) in Leydig cells results in the phosphorylation of ERK1/2 by cAMP dependent and cAMP independent pathways
Fa et al., Toxicol Appl Pharmacol 2013 (MAP Kinase Signaling System) : The results from this study reveal that atrazine does not affect but requires ERK1/2 phosphorylation to cause decrease in the FSH induced LHR and CYP19A1 mRNA levels and estradiol production in immature granulosa cells, thus compromising ovulation and female fertility