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HEY1 — KDR

Pathways - manually collected, often from reviews:

• NCI Pathway Database Notch-mediated HES/HEY network: HEY1 (HEY1) → VEGFR2 (KDR) (transcription, inhibits) Holderfield et al., Biochem Biophys Res Commun 2006*
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Tang et al., Zhonghua Yan Ke Za Zhi 2005 (Neovascularization, Pathologic...) : Over-expression of HESR-1 down-regulated KDR expression, but occludin expression was up-regulated in HRECEs, the result also showed that the vessels permeability was reduced by HESR-1
Holderfield et al., Biochem Biophys Res Commun 2006 : Thus, HESR1 represses VEGFR2 through interactions with SP-1-like factors and requires an Inr element in the absence of a TATA box