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HCL2 — LEO1

Text-mined interactions from Literome

Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006 (Disease Models, Animal...) : Platelet activating factor (PAF) and interleukin-6 (IL-6) are produced in the esophagus in response to HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis ( Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett KM. Am J Physiol Gastrointest Liver Physiol 289 : G418-G428, 2005 )
Cheng et al., J Pharmacol Exp Ther 2006 (Esophagitis) : HCl increased PAF and interleukin (IL)-1beta ( but not IL-6, prostaglandin E ( 2 ), or H ( 2 ) O ( 2 ) ) in mucosa, and only PAF was released into the supernatant, presumably to affect circular muscle
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2009 : In epithelial cells PAF increased in response to HCl , and the increase was abolished by IRTX
Ma et al., Am J Physiol Gastrointest Liver Physiol 2011 : In esophageal mucosa, HCl causes TRPV1 mediated release of calcitonin gene related peptide (CGRP) and substance P ( SP ) from submucosal neurons and of platelet activating factor (PAF) from epithelial cells