◀ Back to EGF
EGF — ERBB2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of EGFR-ERBB2
→
EGF
(directlyIncreases)
Evidence: Figure 1 , ERBB receptors, ligands, dimers and downstream signalling pathways. a , Members of the epidermal growth factor (EGF) family of growth factors are ligands for the ERBB receptors. Ligand binding to ERBB receptors induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues within the cytoplasmic tail. These phosphorylated residues serve as docking sites for a range of proteins, the ...
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KEGG Focal adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC
→
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
(protein-protein, activation)
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KEGG Prostate cancer:
EGF/IGF1/INS/PDGFA/PDGFB/PDGFC/PDGFD/TGFA
→
EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB
(protein-protein, activation)
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KEGG Bladder cancer:
EGF
→
ERBB2
(protein-protein, activation)
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KEGG Non-small cell lung cancer:
EGF
→
ERBB2
(protein-protein, activation)
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NCI Pathway Database ErbB receptor signaling network:
EGF (EGF)
→
ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1)
(modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
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NCI Pathway Database ErbB receptor signaling network:
EGF (EGF)
→
ErbB2 (ERBB2)
(modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
-
NCI Pathway Database ErbB receptor signaling network:
EGF (EGF)
→
EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF)
(modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
-
NCI Pathway Database ErbB receptor signaling network:
HSP90 (dimer) complex (HSP90AA1)
→
EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF)
(modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
-
NCI Pathway Database ErbB receptor signaling network:
ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1)
→
EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF)
(modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
-
NCI Pathway Database ErbB receptor signaling network:
ErbB2 (ERBB2)
→
EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF)
(modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
-
NCI Pathway Database ErbB receptor signaling network:
EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF)
→
EGFR (EGFR)
(modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
EGF/EGFR complex (EGF-EGFR)
→
ErbB2 (ERBB2)
(modification, activates)
Russell et al., J Cell Sci 2003, Yoon et al., Cancer Res 2006
Evidence: assay
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Reactome Reaction:
EGF
→
ERBB2
(indirect_complex)
-
Reactome Reaction:
EGF
→
ERBB2
(reaction)
Borg et al., Nat Cell Biol 2000, Xu et al., J Biol Chem 2001, Vijapurkar et al., Exp Cell Res 2003, Citri et al., EMBO Rep 2004, Xu et al., Nature structural & molecular biology 2005, Fazioli et al., Mol Cell Biol 1991*, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Kaushansky et al., Chem Biol 2008, Wada et al., Cell 1990, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Karunagaran et al., EMBO J 1996, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996, Cohen et al., J Biol Chem 1996*
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WikiPathways Focal Adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC
→
BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kim et al., J Biol Chem 1999
:
Although
EGF enhanced
ErbB-2 tyrosine phosphorylation, GH, while causing retardation of its migration on SDS-polyacrylamide gel electrophoresis, decreased ErbB-2 's tyrosine phosphorylation
Klapper et al., Cancer Res 2000
(Stomach Neoplasms) :
To understand the mechanism underlying immunotherapy, we concentrated on antibody- and
epidermal growth factor induced degradation of
ErbB-2
Satoh et al., Arthritis Rheum 2001
(Arthritis, Rheumatoid) :
EGF stimulated the phosphorylation of
ErbB-2 in primary synovial cells with RA
Johannessen et al., Biochem J 2001
:
Furthermore, the
EGF induced tyrosine phosphorylation of
ErbB2 was not affected by overexpression of [ K44A ] dynamin, implying that EGFR-ErbB2 dimers were fully functional
Zhou et al., Oncogene 2001
:
The data herein demonstrate that heregulin or betacellulin, but not
EGF ,
promotes the rapid translocation of
ErbB-2 , the heterodimerization partner for ErbB-4, to the same detergent-insoluble fraction in T47 D mammary carcinoma cells
Ewald et al., Exp Cell Res 2001
:
Our results indicate that while there are measurable differences in the abilities of the two mutant receptors to stimulate [ ( 3 ) H ] thymidine incorporation between 20 and 24 h after addition of EGF, these differences can not be correlated with significant differences in
EGF stimulated tyrosine phosphorylation of mutant EGF receptor and endogenous
ErbB2 , the extent of receptor internalization, EGF stimulated ion uptake, stimulation of SHC activity, or receptor association with Grb2
Wagner et al., Gastroenterology 2002
:
AR
induced a slight induction of
ErbB2 on duct cells, whereas TGF-alpha resulted in overexpression of the
EGF receptor in cells within tubular complexes
Huang et al., J Biol Chem 2003
:
For ErbB-2, GH induces serine/threonine phosphorylation that dampens basal and
EGF induced
ErbB-2 kinase activation
Dowlati et al., Mol Cancer Ther 2004
:
Our study suggests that residual
ErbB2 activation by
EGF , despite EGFR blockade, is responsible for persistent downstream activation of Stat-3
Guo et al., Biochim Biophys Acta 2004
:
In SK-OV-3 human ovarian cancer cells and SK-BR-3 human breast carcinoma cells, ZH-4B blocks
epidermal growth factor (EGF) induced phosphorylation of
ErbB-2 in a dose dependent manner
Scheving et al., Am J Physiol Gastrointest Liver Physiol 2006
:
Although ErbB2 was not present in freshly isolated hepatocytes,
EGF and insulin independently
induced ErbB2 while suppressing ErbB3 expression ... Maximal
EGF stimulation of DNA synthesis in vitro depends on the induction of ErbB2 and
involves an
EGFr-ErbB2 heterodimer
Weng et al., Toxicol Appl Pharmacol 2007
(Breast Neoplasms...) :
Treatment with TNQ inhibited
EGF induced
EGFR/ErbB-2 phosphorylation and dimerization
Martin et al., Mol Pharmacol 2008
:
Coexpression of dominant negative ERBB1 and dominant negative ERBB2 inhibited basal and
EGF stimulated ERBB1 and
ERBB2 phosphorylation in parental and adapted cells
Liu et al., Microvasc Res 2009
:
The
epidermal growth factor (EGF)-repeats of TSP1
activate the ( EGF ) receptor ( EGFR ) and
ErbB2 , and these two receptor protein tyrosine kinases ( PTK ) s participate in ZA protein tyrosine phosphorylation and barrier disruption in response to the TSP1 stimulus
Liu et al., PloS one 2009
:
ErbB2 is resistant to stimulus induced degradation and high levels of over-expression can
inhibit EGF receptor down-regulation
Milani et al., Biochim Biophys Acta 2010
:
Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify
EGF dependent
ErbB2 phosphorylation
Bachawal et al., BMC cancer 2010
(Mammary Neoplasms, Animal) :
Combined treatment of gamma-tocotrienol with erlotinib or gefitinib also cause a large decrease in ErbB3, ErbB4, and to a lesser extent ErbB2 receptor levels, and
EGF dependent
ErbB2-4 tyrosine phosphorylation ( activation ), but had no effect on ErbB1 receptor levels or activation
Huang et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2010
:
c-erbB2 mRNA existed in the oocytes endochylema and
ErbB2 existed in the oocytes membrane, the expressions of c-erbB2 mRNA and ErbB2 appeared to be more intense when primordial follicles were cultured for 8 d than cultured for 0 d in the Waymouth culture system and were further
increased with 50 ng/ml
EGF for 4 d and 8 d
Yoshida et al., Jpn J Cancer Res 1990
(Carcinoma...) :
Both EGF and TGF-alpha stimulated EGFR phosphorylation,
EGF and TGF-alpha
induced FOS, MYC and
ERBB-2 oncogene expression
Meijer et al., Cell Signal 2012
:
In contrast,
EGF activation of
EGFR-ErbB2 showed significantly decreased Hrs tyrosine phosphorylation and deubiquitination by AMSH
Antoniotti et al., Br J Cancer 1994
(Breast Neoplasms) :
We observed that both oestrogen and
EGF comparably
down-regulated p185erbB-2 levels, while stimulating growth of T47D and ZR75.1 cells
Sasaoka et al., J Biol Chem 1996
:
EGF markedly
increased ErbB2 tyrosine phosphorylation in wild type EGFR cells
Nowak et al., Biochem Pharmacol 1997
:
On the contrary, it prolonged the
EGF dependent EGF-R and
p185erbB2 ( V-E ) tyrosine phosphorylation in p185erbB2 ( V-E ) -expressing cells
Graus-Porta et al., EMBO J 1997
(Vulvar Neoplasms) :
Furthermore,
EGF- and BTC induced activation of ErbB-3 is
impaired in the absence of
ErbB-2 , suggesting that ErbB-2 has a role in the lateral transmission of signals between other ErbB receptors
Crusius et al., Exp Cell Res 1998
:
In addition, treatment with
EGF results in an enhanced activation of the
ErbB2 receptor in E5-expressing cells
Krymskaya et al., Am J Physiol 1999
:
EGF activates
ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells