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CARD10 — NFKB1
Text-mined interactions from Literome
Koseki et al., J Biol Chem 1999
:
Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the
CARD is
essential for
NF-kappaB activation and dimerization
Bertin et al., J Biol Chem 2000
:
When expressed in cells,
CARD9 binds to BCL10 and
activates NF-kappaB
Bertin et al., J Biol Chem 2001
:
When expressed in cells,
CARD11 and CARD14
activate NF-kappaB and induce the phosphorylation of BCL10
McAllister-Lucas et al., Proc Natl Acad Sci U S A 2007
(Inflammation) :
CARMA3/Bcl10/MALT1 dependent
NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells
Grabiner et al., Genes Dev 2007
:
Together, our results provide the genetic evidence that
CARMA3 is
required for GPCR induced
NF-kappaB activation
Fontalba et al., J Immunol 2007
(Arthritis, Rheumatoid) :
Thus,
CARD8 may
control NF-kappaB activation through a regulatory loop
Medoff et al., Am J Respir Cell Mol Biol 2009
(Asthma) :
Here we demonstrate that CARMA3 ( CARD10 ) is specifically expressed in human airway epithelial cells, and that expression of
CARMA3 in these cells
leads to activation of
NF-kappaB ... We then show that inhibition of
CARMA3 activity in airway epithelial cells
reduces LPA mediated
NF-kappaB activity and the production of TSLP and CCL20 ... In conclusion, these data demonstrate that LPA stimulates TSLP and CCL20 expression in bronchial epithelial cells via
CARMA3 mediated
NF-kappaB activation
Marasco et al., Biochem J 2009
:
When tested in cell assays for its capacity to block NF-kappaB activation, this peptide represses activation of
NF-kappaB mediated by BCL10,
CARMA3 and PMA/ionomycin stimulation
McAllister-Lucas et al., J Biol Chem 2010
(Atherosclerosis...) :
Emerging evidence suggests that
CARMA3 can substitute for CARMA1 in non-immune cells to assemble a CARMA3-Bcl10-MALT1 signalosome and
mediate G protein coupled receptor activation of
NF-kappaB