Gene interactions and pathways from curated databases and text-mining

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FXR1 — IRF6

Text-mined interactions from Literome

Li et al., Vet Res 2011 : Several pathways, such as FXR/RXR activation , LXR/RXR activation, LPS/IL-1 mediated inhibition of RXR function, and arachidonic acid metabolism, were impacted in resistant animals, which are potentially involved in the development of parasite resistance in cattle
Renga et al., PloS one 2013 (Colitis...) : In addition to its role in regulating type-I interferons and innate antiviral immunity, IRF-7 a TLR9 dependent factor, regulates the expression of FXR , linking microbiota sensing receptors to host 's immune and metabolic signaling
Olsvik et al., Ecotoxicol Environ Saf 2013 : According to the IPA analyses, the top toxicity list ranking was `` LXR/RXR activation '', `` Negative/Positive acute phase response proteins '', "LPS/IL-1 mediated inhibition of RXR function '' and `` FXR/RXR activation ''