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EPHB2 — SLC9A1
Text-mined interactions from Literome
Mukhin et al., J Biol Chem 2004
:
Inhibition of
NHE-1 with pharmacological agents or by isotonic replacement of sodium in the perfusate with choline or tetramethylammonium greatly
attenuated ERK activation by 5-HT or Ang II ... Receptor independent activation of
NHE-1 by acute acid loading of RASM cells
resulted in the rapid phosphorylation of
ERK , which could be blocked by pharmacological inhibitors of NHE-1 or by isotonic replacement of sodium, closely linking the proton transport function of NHE-1 to ERK activation
Azriel-Tamir et al., J Biol Chem 2004
:
Activation of
NHE1 by zinc was totally blocked by the
ERK1/2 inhibitor, U0126
Wallert et al., Cell Signal 2005
:
The data indicate that
ERK activation is
essential for phenylephrine stimulation of
NHE1 , and that ERK and RhoA are involved in LPA stimulation of NHE1 by more than one mechanism ... These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of NHE1 and a significant
role for both
ERK and RhoA in LPA stimulation of
NHE1 in CCL39 fibroblasts
Kintner et al., Am J Physiol Cell Physiol 2005
(Calcium Signaling) :
Together, our data suggest that
ERK1/2 is
involved in activation of
NHE1 in astrocytes after in vitro ischemia
Cechin et al., Neurochem Res 2005
(Glioma) :
Inhibition of Rho kinase or
NHE1 did not
reduce the LPA induced phosphorylation of
ERK , Akt or CREB
Konstantinidis et al., Cell Physiol Biochem 2006
:
Additionally, inhibition of
NHE1 resulted in
ERK inhibition as well
Pedersen et al., Cell Physiol Biochem 2007
(Carcinoma, Ehrlich Tumor) :
Here, we show, using a combination of biochemical and molecular biology approaches, that three MAPKs exhibit unique interrelationships with the Na ( + ) /H ( + ) exchanger, NHE1, after osmotic cell shrinkage : Extracellular Signal Regulated Kinase ( ERK1/2 ) is inhibited in an NHE1 dependent, pH(i) independent manner, c-Jun N-terminal kinase (JNK1/2) is stimulated, in part through NHE1 mediated intracellular alkalinization, and p38 MAPK is activated in an NHE1 independent manner, and contributes to
NHE1 activation and
ERK inhibition ... Shrinkage induced
ERK1/2 inhibition was
attenuated in Ehrlich Lettre Ascites cells by
NHE1 inhibitors ( EIPA, cariporide ) or removal of extracellular Na ( + ), and mimicked by human ( h ) NHE1 expression in cells lacking endogenous NHE1 activity ... The
effect of
NHE1 on
ERK1/2 was pH(i) independent and upstream of MEK1/2
Coccaro et al., Am J Physiol Heart Circ Physiol 2009
(Acidosis...) :
We recently demonstrated that
extracellular regulated kinase (ERK) mediated activation of
NHE1 occurs during ischemia-reperfusion of the myocardium ... The same amino acids were critical to phenylephrine mediated,
ERK dependent activation of
NHE1 activity and increased the phosphorylation in intact rat cardiomyocytes