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EPHB2 — SETD2

Text-mined interactions from Literome

Minet et al., FEBS Lett 2000 : In this report, we investigated the activation of extracellular regulated kinases (ERK) in hypoxia and their involvement in HIF-1 activation
Mottet et al., J Cell Physiol 2003 (Calcium Signaling) : Role of ERK and calcium in the hypoxia induced activation of HIF-1
Schweppe et al., J Biol Chem 2006 (Anoxia) : Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5 mediated responses
Sutton et al., Oncogene 2007 : Conversely, treatment of tumour cells with the MEK1/2 inhibitors PD98059 or U0216, or expression of a dominant negative form of ERK1 blocked HIF-1 activation in hypoxia without affecting HIF-1alpha induction, localization or binding of HIF-1beta
Zhang et al., Cancer Lett 2011 (Anoxia...) : Furthermore, the expression of HIF-1a induced by SCF is not dependent on the oxygen level, but rather on both the PI3K/Akt and Ras/MEK/ERK signaling pathways
Luwor et al., Cancer Lett 2011 (Carcinoma, Squamous Cell...) : Compared with corresponding control cells, A431-Ras cells exhibited marked resistance to the EGFR inhibitors cetuximab and gefitinib, reducing inhibition of Akt and Erk phosphorylation, inhibition of HIF-1a expression and transcriptional activity, and antitumor effects in vitro and in vivo
Liu et al., PloS one 2011 (Neovascularization, Pathologic) : The AKT and ERK inhibitors, LY294002 and U0126, suppressed HIF-1a and VEGF expression and angiogenesis
Du et al., PloS one 2011 (Breast Neoplasms) : PI3K and ERK induced Rac1 activation mediates hypoxia induced HIF-1a expression in MCF-7 breast cancer cells
Wu et al., J Pathol 2011 (Endometriosis) : In contrast, forced expression of DUSP2 under hypoxia abolishes HIF-1a induced ERK phosphorylation and COX-2 expression
Wu et al., PloS one 2012 : Inhibition of ERK1/2 using UO126 or PD98059 reduced but did not abolish OA-NO ( 2 ) -induced HIF-1a upregulation, suggesting that OA-NO ( 2 ) /HO-1 initiated HIF-1a induction is partially dependent on ERK1/2 activity
Yang et al., Oncogene 2013 (Melanoma...) : In conclusion, our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of HIF-1a and VEGF expressions mediated by RAS-RAF-MEK-ERK signaling
Paweł et al., Lipids 2013 (Leiomyoma...) : Additionally, in uterine leiomyomas we found relevant activation of both PTEN and MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent HIF-1a/AMPK activation
Fu et al., PloS one 2013 : BBR also downregulated HIF-1a and VEGF expression and inhibited Akt and ERK phosphorylation
Shin et al., PloS one 2013 (Neovascularization, Pathologic...) : Mechanistically, MEL specifically inhibited the EGF induced HIF-1a expression by suppressing the phosphorylation of ERK , mTOR and p70S6K