Gene interactions and pathways from curated databases and text-mining

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IRS1 — PIK3C2G

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: PIK3CD/PIK3C3/PIK3R3/PIK3R1/PIK3C2G/PIK3R2/PIK3CG/PIK3CB/PIK3R4/PIK3C2A/PIK3CA → Complex of IRS1-PIK3CA (activation)
  • WikiPathways DNA Damage Response (only ATM dependent): IRS1 → PIK3CA/PIK3CB/PIK3CG/PIK3CD/PIK3R1/PIK3R2/PIK3R3/PIK3R4/PIK3R5/PIK3C2A/PIK3C2B/PIK3C2G/PIK3C3 (activation)