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F12 — PLG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Schousboe et al., Thromb Haemost 1999
:
Activation of
plasminogen by
factor XIIa followed the Michaelis-Menten rate equation ... Comparing the catalytic constants of factor XIIa with those of urokinase activation of plasminogen, the specificity constant, kcat/Km, of
factor XIIa activation of
plasminogen was 20-fold lower ... When monitoring
factor XIIa activation of
plasminogen in a clot lysis assay, the clot lysis time was 2- to 4-fold as long as that accommodated by urokinase at factor XIIa concentrations equivalent with 5-20 % of the zymogen concentration in plasma
Talbot et al., Biochim Biophys Acta 2010
:
We previously showed that
coagulation factor Xa (FXa)
enhances activation of the fibrinolysis zymogen
plasminogen to plasmin by tissue plasminogen activator (tPA)
Ogiwara et al., Blood Coagul Fibrinolysis 2010
:
Generation of thrombin in these circumstances appears to be owing to
plasmin (Plm) induced activation of
factor (F) XII
Derhaschnig et al., J Hum Hypertens 2013
(Emergencies...) :
We compared markers of coagulation, fibrinolysis ( prothrombin fragment
F1+2 , plasmin-antiplasmin complexes,
plasmin-activator inhibitor , tissue plasminogen activator ), platelet- and endothelial activation and inflammation ( P-selectin, C-reactive protein, leukocyte counts, fibrinogen, soluble vascular adhesion molecule-1, intercellular adhesion molecule-1, myeloperoxidase and asymmetric dimethylarginine ) between hypertensive emergencies, urgencies and normotensive patients
Goldsmith et al., J Clin Invest 1978
:
The
activation of
plasminogen by
Hageman factor ( Factor XII ) and Hageman factor fragments
Schousboe et al., Blood Coagul Fibrinolysis 1997
:
Here
activation of Glu- and
Lys-plasminogen by
factor XIIa in the absence of prekallikrein/kallikrein and high Mr kininogen was studied in a purified system by the generation of amidolytic activity towards pyroGlu-Phe-Lys-pNA ( S-2403 ), a chromogenic substrate of plasmin