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CBL — IRS1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Insulin Pathway: CBL (CBL) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Baumann et al., Nature 2000, Liu et al., Mol Cell Biol 2002, Hu et al., Mol Cell 2003, Ribon et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CBL — IRS1 (physical association, affinity chromatography technology) Ahmed et al., FEBS Lett 2000*

Text-mined interactions from Literome

Standaert et al., Biochemistry 2004 : In contrast to Cbl dependent PI 3-kinase, Cbl mutants did not significantly inhibit the activation of PI 3-kinase by IRS-1 , which is also required during insulin action
Miura et al., Biochemistry 2004 : We have also used these adipocytes to see if IRS-1 and IRS-2 are required for activation of Cbl , which is required for insulin stimulated glucose transport and has been found to function upstream of both PI3K/aPKC and Crk during thiazolidinedione action in 3T3/L1 adipocytes [ Miura et al. ( 2003 ) Biochemistry 42, 14335 ] ... These findings provide evidence that directly links both IRS-1 and IRS-2 to aPKC activation in immortalized brown adipocytes, and further suggest that IRS-1 and IRS-2 are required for the activation of Cbl/PI3K during insulin action in these cells