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IL2 — ODC1

Text-mined interactions from Literome

Wang et al., Anticancer Res 2002 (MAP Kinase Signaling System) : We demonstrated that PA inhibited ODC activity induced by IL2 in a time- and dose dependent manner
McCarthy et al., Immunopharmacology 1990 : To examine the mechanism of action of DFMO, we studied the effect of this ODC inhibitor on lymphokine production and interleukin 2 (IL 2) receptor expression ... Concentrations of IL 2 increased 7-fold in DFMO treated, PHA stimulated PBMC cultures, compared with untreated cells ; whereas IL 2 receptor expression as measured by the anti-Tac monoclonal antibody was not affected by the inhibition of ODC
Legraverend et al., Exp Cell Res 1989 : These findings suggest that the regulation of the ODC activity by IL-2 is a primary event in IL-2 induced cell proliferation and occurs at the post-transcriptional level, possibly by stabilizing the ODC mRNA and affecting the efficiency of translation of the messenger
Legraverend et al., Exp Cell Res 1989 : H-7, a potent inhibitor of PKC and cyclic nucleotide dependent protein kinases ( CN-PK ), suppressed the IL-2 induced ODC activity, while HA1004, a more potent inhibitor of CN-PK than of PKC, had opposite effects depending on its concentration ... The results suggest that activation of PKC is involved in but is not the sole mechanism for the induction of ODC by rec IL-2
Farrar et al., J Immunol 1988 : IL-2 regulates the expression and activation of the principal rate limiting enzyme of polyamine synthesis, ornithine decarboxylase (ODC)
Fidelus et al., J Immunol 1984 : Interleukin 2 (IL 2) and IL 2-containing supernatants were also capable of increasing ODC activity in T lymphocytes in the absence of monocytes
Fidelus et al., Transplantation 1984 : We conclude that ( 1 ) the induction of ODC in human lymphocytes by mitogen and alloantigen is inhibited in the presence of cyclosporine ; ( 2 ) the induction of ODC activity in purified T lymphocytes requires the presence of both mitogen and monocytes or their products ; ( 3 ) IL-1 and IL-2 can supplement for monocytes and augment the phytohemagglutinin induction of ODC in T lymphocytes ; and ( 4 ) cyclosporine inhibits ODC induction in T lymphocytes stimulated with mitogen in the added presence of monocytes, IL-1, or IL-2