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EZH2 — TP53
Text-mined interactions from Literome
Tang et al., Oncogene 2004
:
Activated
p53 suppressed
EZH2 gene expression through repression of the EZH2 gene promoter ... We suggest that the
p53 dependent suppression of
EZH2 expression is a novel pathway that contributes to p53 mediated G2/M arrest
Cheng et al., Clin Cancer Res 2012
(Stomach Neoplasms) :
In primary human gastric cancers, EZH2 expression was negatively correlated with p53 pathway activation, suggesting that higher levels of
EZH2 may
repress p53 activity
Seward et al., Cancer Lett 2013
(Neoplasm Invasiveness...) :
EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21 ( waf1/cip1 ) and by
inhibiting mutant
p53 ... Further, silencing of
EZH2 resulted in re-expression of p21 ( waf1/cip1 ) and down-regulation of mutant
p53
Mahamodhossen et al., Med Oncol 2013
:
Some of these markers are
p53 induced miR-205, leptin receptor antagonist peptide,
enhancer of zeste homolog 2 and Notch 1 pathway components, each of them could offer different mechanism for target therapy in TNBC