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ATG5 — TP53
Text-mined interactions from Literome
Ghavami et al., PloS one 2011
:
Notably both mevalonate cascade inhibition induced autophagy and apoptosis were p53 dependent : simvastatin increased nuclear
p53 accumulation, and both cyclic pifithrin-a and p53 shRNAi partially
inhibited NOXA, PUMA expression and caspase-3/7 cleavage ( apoptosis ) and DRAM expression,
Atg5-12 complex formation, LC3 lipidation, and autophagosome formation ( autophagy )
Gao et al., Cell Death Differ 2011
:
The
upregulation of ULK1 ( ULK2 )
/ATG13 complex by
p53 is necessary for the sustained autophagy activity induced by DNA damage