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BRCA1 — HDAC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: HDAC1 — BRCA1 Yarden et al., Proc Natl Acad Sci U S A 1999*
• IRef Bind_translation Interaction: HDAC1 — BRCA1 (affinity chromatography technology) Yarden et al., Proc Natl Acad Sci U S A 1999*
• IRef Biogrid Interaction: HDAC1 — BRCA1 (direct interaction, pull down) Yarden et al., Proc Natl Acad Sci U S A 1999*
• MIPS CORUM BRCA1-HDAC1-HDAC2 complex: BRCA1-HDAC1-HDAC2 complex complex (BRCA1-HDAC1-HDAC2) Yarden et al., Proc Natl Acad Sci U S A 1999*
• IRef Corum Interaction: Complex of BRCA1-HDAC2-HDAC1 (association, anti tag coimmunoprecipitation) Yarden et al., Proc Natl Acad Sci U S A 1999*
• IRef Hprd Interaction: HDAC1 — BRCA1 (in vitro) Yarden et al., Proc Natl Acad Sci U S A 1999*
• IRef Hprd Interaction: HDAC1 — BRCA1 (in vivo) Yarden et al., Proc Natl Acad Sci U S A 1999*
• IRef Ophid Interaction: HDAC1 — BRCA1 (aggregation, confirmational text mining) Yarden et al., Proc Natl Acad Sci U S A 1999*
• IRef Ophid Interaction: HDAC1 — BRCA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Park et al., Nucleic Acids Res 2008 : Consistently, silencing of SUMO1 led to recruitment of BRCA1 and release of HDAC1 at the BRCA1 target promoters, and subsequent transcriptional activation of the BRCA1 target genes
Di et al., Nature structural & molecular biology 2010 : Loss of CtBP from the BRCA1 promoter through estrogen induction, depletion by RNA interference or increased NAD+/NADH ratio leads to HDAC1 dismissal, elevated histone acetylation and increased BRCA1 transcription
Yu et al., J Biol Chem 1998 : This finding suggests that BRCA1 regulates gene expression, at least in part, by modulating CtBP mediated transcriptional repression