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CSE — TLR4

Text-mined interactions from Literome

Pace et al., Immunology 2008 : The main goal of this study was to explore the effects of cigarette smoke extracts (CSE) on Toll-like receptor ( TLR ) expression and activation in a human bronchial epithelial cell line ( 16-HBE ) ... The CSE increased the expression of TLR4 and the lipopolysaccharide (LPS) binding, the nuclear factor-kappaB (NF-kappaB) activation, the release of interleukin-8 (IL-8) and the chemotactic activity toward neutrophils
Pace et al., Cell Immunol 2011 (Tobacco Use Disorder) : CSE increased TLR4 expression, reduced IP-10 release and lymphocyte chemotactic activity and increased IL-8 release and neutrophil chemotactic activity
Comer et al., PloS one 2012 (Pulmonary Disease, Chronic Obstructive) : CSE reduced TLR-4 expression in bronchial cells only after 24 h, and was without effect on mRNA expression