UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database ErbB receptor signaling network: HSP90 (dimer) complex (HSP90AA1) → neuregulin 1 beta (NRG1) (modification, collaborate) Xu et al., J Biol Chem 2001, Citri et al., EMBO Rep 2004
Evidence: mutant phenotype, physical interaction
NCI Pathway Database ErbB receptor signaling network: HSP90 (dimer) complex (HSP90AA1) → ErbB2/ErbB3/neuregulin 1 beta complex (ERBB2-ERBB3-NRG1) (modification, collaborate)
Xu et al., J Biol Chem 2001, Citri et al., EMBO Rep 2004
Evidence: mutant phenotype, physical interaction
NCI Pathway Database ErbB receptor signaling network: neuregulin 1 beta (NRG1) → ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1) (modification, collaborate)
Xu et al., J Biol Chem 2001, Citri et al., EMBO Rep 2004
Evidence: mutant phenotype, physical interaction
NCI Pathway Database ErbB receptor signaling network: ErbB2/ErbB3/neuregulin 1 beta complex (ERBB2-ERBB3-NRG1) → ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1) (modification, collaborate)
Xu et al., J Biol Chem 2001, Citri et al., EMBO Rep 2004
Evidence: mutant phenotype, physical interaction
Reactome Reaction: HSP90AA1 → NRG1 (reaction) Borg et al., Nat Cell Biol 2000, Xu et al., J Biol Chem 2001, Citri et al., EMBO Rep 2004, Xu et al., Nature structural & molecular biology 2005, Li et al., Cell Signal 2007, Wada et al., Cell 1990, Karunagaran et al., EMBO J 1996, Pinkas-Kramarski et al., EMBO J 1996