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IGF1 — WT1

Text-mined interactions from Literome

Idelman et al., J Biol Chem 2003 (Bone Neoplasms...) : In the presence of mutant p53, WT1 can not repress the IGF-IR promoter
Bentov et al., Endocrinology 2003 : In the present study, we demonstrated that IGF-I reduced WT1 expression in osteosarcoma derived Saos-2 cells in a time- and dose dependent manner
Werner et al., Mol Cell Biol 1995 (Wilms Tumor) : To study whether WT1 could suppress the expression of the endogenous IGF-I-R gene, WT1 negative G401 cells were stably transfected with a WT1 expression vector
Werner et al., Adv Exp Med Biol 1993 (Kidney Neoplasms...) : Future studies will define whether other disease states in which the IGF-I-R gene is highly expressed are also associated with loss of negative regulation of the IGF-I-R promoter by WT1 or other tumor suppressor gene products
Karnieli et al., J Biol Chem 1996 (Cell Transformation, Neoplastic...) : Because WT1 has been shown previously to bind and repress the insulin-like growth factor I ( IGF-I-R ) promoter, we investigated whether this promoter is, in addition, a target for the aberrant EWS/WT1 transcription factor ... EWS/WT1 activated the IGF-I-R promoter approximately 340 %, whereas a fusion protein containing a three-amino acid insert ( KTS ) between zinc fingers 3 and 4 had no effect