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CA2 — PARP1

Text-mined interactions from Literome

Abdallah et al., Cardiovasc Res 2007 (MAP Kinase Signaling System) : Inhibition of NAD ( P ) H oxidase with antisense oligonucleotide against the p22(phox) subunit, MEK/ERK signalling with UO 126 ( 30 microM ), or PARP with PJ 34 ( 10 microM ) leads to a marked reduction in hypoxia induced cytosolic Ca2+ load and activation of PARP
Oestreich et al., J Biol Chem 2009 (Calcium Signaling) : Here we demonstrate that PLCepsilon phosphatidylinositol 4,5-bisphosphate hydrolytic activity and PLCepsilon stimulated Rap1 GEF activity are both required for PLCepsilon mediated enhancement of sarcoplasmic reticulum Ca2+ release and that PLCepsilon significantly enhances Rap activation in response to betaAR stimulation in the heart
Geistrikh et al., Biochem J 2011 : Ca2+ induced PARP-1 activation and ANF expression are coupled events in cardiomyocytes
Guidetti et al., Biochem J 2013 : In blood platelets the small GTPase Rap1b is activated by cytosolic Ca2+ and promotes integrin aIIbß3 inside-out activation and platelet aggregation
Ubol et al., J Virol 1996 (Neuroblastoma) : We conclude that SV-induced apoptosis of neuroblastoma cells is dependent on viral replication, is not dependent on a rise in intracellular Ca2+ , and is accompanied by activation of PARP and of a protease that cleaves PARP
Kawasaki et al., Proc Natl Acad Sci U S A 1998 : We propose that CalDAG-GEF proteins have a critical neuronal function in determining the relative activation of Ras and Rap1 signaling induced by Ca2+ and DAG mobilization