◀ Back to EPHB2

EPHB2 — SPP1

Text-mined interactions from Literome

Moses et al., Arch Biochem Biophys 2001 : Injury induced osteopontin gene expression in rat arterial smooth muscle cells is dependent on mitogen activated protein kinases ERK1/ERK2 ... We conclude that ERK1/ERK2 are involved in the regulation of osteopontin expression in cultured vascular smooth muscle cells
Beck et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The second ERK1/2 activation is required for osteopontin regulation, whereas the first is not sufficient
Das et al., J Biol Chem 2004 (Breast Neoplasms...) : Furthermore, OPN induces alpha(v)beta(3) integrin/EGFR mediated ERK1/2 phosphorylation and AP-1 activation ... OPN induced ERK phosphorylation, AP-1 activation, uPA secretion, and cell motility were suppressed when cells were transfected with dn c-Src or pretreated with alpha(v)beta(3) integrin antibody, c-Src kinase inhibitor ( pp2 ), EGFR tyrosine kinase inhibitor ( PD153035 ), and MEK-1 inhibitor ( PD98059 )
Rangaswami et al., J Biol Chem 2005 (Neoplasm Invasiveness) : But this did not affect the OPN induced NIK dependent ERK1/2 activation
Wu et al., J Cell Biochem 2006 : The ERK inhibitor ( PD98059 ) blocked Elk-1 phosphorylation, as well as COL1 and OPN gene expression
Schapira et al., Cancer Res 2006 (Cell Transformation, Neoplastic) : Inhibition of ERK phosphorylation in NIH/oncVav1 cells led to a decrease in osteopontin expression, implying that the elevated osteopontin expression in these cells is dependent on ERK phosphorylation
Abe et al., Hypertens Res 2008 : Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK , Src and Ets-1
Chipitsyna et al., Int J Cancer 2009 (Carcinoma, Pancreatic Ductal...) : Inhibition of ERK1/2 activation reduced the nicotine induced OPN synthesis
Dai et al., Oncogene 2009 : Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells
Hong et al., Mol Cell Biochem 2010 : Activation of RhoA and FAK induces ERK mediated osteopontin expression in mechanical force subjected periodontal ligament fibroblasts ... Further, ERK inhibitor inhibited significantly OPN expression, Elk1 phosphorylation, and activator protein-1 (AP-1)-DNA binding activation, but not FAK phosphorylation, in the force applied cells
Camalier et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Cell Transformation, Neoplastic...) : Supplementation of medium with phosphate increased anchorage independent transformation and proliferation of BALB/c mouse JB6 epidermal cells, activation of N-ras, ERK1/2 , and activator protein-1, and increased gene expression of Fra-1, COX-2, and osteopontin in a dose dependent manner
Kumar et al., PloS one 2013 (Disease Progression...) : Furthermore, host OPN induces VEGF, ABCG2 and ERK1/2 expression and activation in B16-WT cells