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CFTR — KRT18
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Stanke et al., BMC medical genetics 2011
(Cystic Fibrosis) :
KRT8, but not
KRT18 , showed an association with CF disease severity ( Pbest=0.00131 ; Pcorr=0.0185 ) and
CFTR mediated residual chloride secretion ( Pbest=0.0004 ; Pcorr=0.0069 )
Duan et al., J Biol Chem 2012
(Cystic Fibrosis) :
Overexpression of
K18 in cells robustly
increased the surface expression of wild-type
CFTR , whereas depletion of K18 through RNA interference specifically diminished it ...
K18 binding
increased the surface expression of
CFTR by accelerating its apical recycling rate without altering CFTR biosynthesis, maturation, or internalization ... Taken together, our results suggest that
K18 increases the cell surface expression of
CFTR by interacting with the CFTR C-terminal hydrophobic patch