Huang et al., Oncogene 2004
(Colonic Neoplasms...) :
Vitamin D3 receptor/Sp1 complex is required for the induction of p27Kip1 expression by vitamin D3 ... On the contrary, suppression of Sp1 expression by small interference RNA reduced the stimulation of p27Kip1 promoter activity by vitamin D3 in LNCaP cells
Cheng et al., J Cell Biochem 2006
:
Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex
Huang et al., Biochem Pharmacol 2008
:
SP1 regulated p27/Kip1 gene expression is involved in terbinafine induced human A431 cancer cell differentiation : an in vitro and in vivo study ... Such results suggest that SP1 plays a critical role in the p27/Kip1 gene transcriptional activation that may be subsequently involved in the TB-induced A431 cancer cell differentiation process