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CDK1 — ERBB2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005

Text-mined interactions from Literome

Lee et al., Cancer Res 2002 (Breast Neoplasms) : Thus, Herceptin treatment of ErbB2 overexpressing cells can inhibit ErbB2 mediated Cdc2-Tyr-15 phosphorylation and p21 ( Cip1 ) up-regulation, which allows effective p34 ( Cdc2 ) activation and induction of apoptosis upon Taxol treatment
Yu et al., Mol Cell 1998 (Breast Neoplasms) : Overexpression of p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally upregulates p21Cip1, which associates with p34Cdc2, inhibits Taxol mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol induced apoptosis