Gene interactions and pathways from curated databases and text-mining

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PRL — TCF20

Text-mined interactions from Literome

Wang et al., Mol Endocrinol 1999 (Pituitary Neoplasms) : These studies are consistent with a signaling pathway involving PKC- and Ca2+ dependent activation of MAPK, which leads to phosphorylation of an Ets transcription factor and activation of the PRL promoter
Grattan et al., Endocrinology 2001 : Feedback regulation of PRL secretion is mediated by the transcription factor , signal transducer, and activator of transcription 5b
Augustijn et al., Proc Natl Acad Sci U S A 2002 : The POU-domain transcription factor Pit-1 and Ets-1, a member of the ETS family of transcription factors, can associate in solution and synergistically activate the prolactin promoter by binding to a composite response element in the prolactin promoter
Domínguez-Cáceres et al., Oncogene 2004 : PRL stimulation of W53 cells resulted in Akt translocation to the nucleus, phosphorylation of FKHRL1 transcription factor , and its nuclear exclusion
Paukku et al., Cytokine Growth Factor Rev 2004 : Stat5 was originally identified as a transcription factor that regulates the beta-casein gene in response to prolactin (PRL) , but Stat5 is activated also by several other cytokines and growth factors
Ezzat et al., Mol Endocrinol 2005 : The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility
Hendy et al., Horm Metab Res 2005 (Multiple Endocrine Neoplasia Type 1) : Menin is also required for the activin induced inhibition of prolactin expression mediated by the Smads and the transcription factor , Pit-1
Hilton et al., Mol Endocrinol 2010 (Breast Neoplasms) : Here we show that Elf5, a prolactin induced ETS transcription factor that specifies the mammary secretory cell lineage, is also induced by progestins in breast cancer cells via a direct mechanism
Sharp et al., Bioessays 1990 : The transcription of rat prolactin and growth hormone genes in vitro requires a pituitary transcription factor , specific to certain cell types in the pituitary, which currently appears to be the PUF-I/Pit-1/GHF-1 protein
David et al., Proc Natl Acad Sci U S A 1994 : Prolactin activates the interferon regulated p91 transcription factor and the Jak2 kinase by tyrosine phosphorylation
Sharp et al., Biochem Biophys Res Commun 1995 : The anterior pituitary-specific transcription factor , Pit-1, activates prolactin , growth hormone, TSH beta, growth hormone receptor genes and autoregulates the pit-1 gene
Howard et al., J Biol Chem 1995 : Binding sites for the tissue-specific transcription factor , Pit-1, are required for basal and hormonally induced prolactin gene transcription
Hou et al., Immunity 1995 : We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin induced transcription factor first identified in sheep mammary gland tissue
Nakajima et al., Immunity 1997 : Stat5a was identified as a prolactin induced transcription factor but also is activated by other cytokines, including interleukin-2 (IL-2) and IL-7
Zanger et al., Mol Endocrinol 1999 : The pituitary-specific transcription factor , Pit-1, is necessary to mediate protein kinase A (PKA) regulation of the GH, PRL , and TSH-beta subunit genes in the pituitary