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BCR — SHC1

Pathways - manually collected, often from reviews:

• BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Chronic myeloid leukemia: ABL1/BCR → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCR — SHC1 (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Hprd Interaction: SHC1 — BCR (in vitro) Wilson-Rawls et al., Leukemia 1997*
• IRef Ophid Interaction: BCR — SHC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Harmer et al., J Biol Chem 1999 : Here, we report that cross linking of the BCR induces association between Grb2 and SHIP as well as association between Shc and SHIP
Ingham et al., J Immunol 1999 : Tyrosine phosphorylation of Shc in response to B cell Ag receptor (BCR) engagement creates binding sites for the Src homology 2 (SH2) domain of Grb2 ... We found that both the SH2 domain and phosphotyrosine binding (PTB) domain of Shc are important for BCR induced tyrosine phosphorylation of Shc and the subsequent binding of Grb2 to Shc ... Because the major ligand for the Shc PTB domain is SHIP, we asked whether the interaction of Shc with SHIP was required for BCR induced tyrosine phosphorylation of Shc ... BCR induced tyrosine phosphorylation of Shc could be restored in the these cells by expressing wild-type SHIP but not by expressing a mutant form of SHIP that can not bind to Shc ... This suggests that BCR induced tyrosine phosphorylation of Shc may depend on the binding of SHIP to the Shc PTB domain
Matsuguchi et al., J Biol Chem 1994 (Leukemia, Megakaryoblastic, Acute) : Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL
Harrison-Findik et al., Oncogene 1995 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : P210 BCR/abl tyrosine kinase induces tyrosine phosphorylation of Shc , and activation of p21ras and PI 3-Kinase
Smit et al., Oncogene 1996 (Burkitt Lymphoma) : B-cell antigen receptor (BCR) stimulation induces tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2 ... We reveal here an additional complexity of the BCR induced Shc/Grb2 complex : it contains tyrosine phosphorylated proteins of 130, 110 and 75 kDa ... In summary, we observe that the BCR activates Shc/Grb2- , Grb2- and Crk adaptor complexes of distinct composition, which may allow selective coupling to different signal transduction cascades
Chacko et al., J Immunol 1996 : Further analysis revealed that both maximal phosphorylation of SHIP and its association with Shc require co-clustering with the Fc receptor for IgG ( Fc gamma RII ) rather than stimulation of the BCR alone
Pao et al., J Immunol 1997 (Plasmacytoma) : BCR mediated Shc phosphorylation and recruitment of Grb2 depended on CD45 expression
Harmer et al., Mol Cell Biol 1997 : Cross linking of the B-cell antigen receptor (BCR) induces tyrosine phosphorylation of Shc , which is believed to lead to the activation of Ras