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FOS — SOX9
Text-mined interactions from Literome
Hwang et al., J Biol Chem 2005
:
Inhibition of c-Jun N-terminal kinase or
AP-1 reversed IL-1beta induced suppression of Sox-9, and ectopic expression of c-Jun was
sufficient to cause suppression of
Sox-9 ... Our results collectively suggest that IL-1beta suppresses type II collagen expression in articular chondrocytes by inducing expression and phosphorylation of c-Jun,
AP-1 activation , and subsequent suppression of
Sox-9
Hwang et al., FEBS Lett 2005
:
AP-1 activation
suppressed the expression of
Sox-9 , a major transcription factor regulating type II collagen expression