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EPHB2 — PRKACG

Text-mined interactions from Literome

Hirota et al., Osteoarthritis Cartilage 2000 : Activation of PKA by 8-bromo-cyclic AMP or forskolin, and inhibition of PKC by calphostin C, resulted in a significant decrease in 3TP activity as well as in vitro ERK kinase activity in CRAC
Park et al., Neurosci Lett 2000 : Here we demonstrate that PKA is required for depolarization induced activation of both extracellular signal regulated kinase ( ERK ) and p38 mitogen activated protein ( MAP ) kinase in PC12 cells ... In contrast to the depolarization induced signaling, the ERK and PYK2 activation by bradykinin ( 1 microM ), a G-protein coupled receptor agonist, was not blocked by PKA inhibition
Miggin et al., Biochim Biophys Acta 2001 : Both U46619 and 8-epiPGF ( 2alpha ) induced ERK activations were inhibited by the protein kinase ( PK ) C, PKA and phosphoinositide 3-kinase inhibitors GF109203X, H-89 and wortmannin, respectively, but were unaffected by pertussis toxin
Jiang et al., Proc Natl Acad Sci U S A 2001 : Inhibition of either PKA or MEK1/2 blocked ERK1/2 activation by glucagon ... We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by PKA and that an increase in intracellular calcium concentration is required for maximal ERK activation
Suwa et al., J Biol Chem 2002 : The dominant negative mutant of vinexin beta inhibited the anchorage independent ERK2 activation induced by the PKA inhibitor
Crépieux et al., Arch Biochem Biophys 2002 : In comparison, in the absence of anchorage, ERK1 , 2 were still activated by epidermal growth factor, in a PKA dependent manner
Dajas-Bailador et al., J Neurochem 2002 (MAP Kinase Signaling System...) : In contrast, two structurally different inhibitors of PKA ( KT 5720 and H-89 ) completely prevented the nicotine dependent increase in ERK1/2 activity
Dhillon et al., Mol Cell Biol 2002 : Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for PKA inhibition of ERK and ERK induced gene expression, and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation
Feldman et al., J Biol Chem 2002 : For the beta ( 2 ) AR in HEK-293 cells, where PKA activity is required for ERK activation, expression of GsCT caused a net inhibition of ERK activation
Piiper et al., Biochem Biophys Res Commun 2003 : Chemical inhibition of PKA suppressed forskolin induced EGFR tyrosine phosphorylation and ERK1/2 activation in PC12 cells ... Together, our data indicate that activation of PKA mediates the effects of cAMP on the EGFR and ERK1/2
Horgan et al., Exp Cell Res 2003 : However, PKA activity was also not necessary for the early translocation of Erk into the nucleus by NGF or Ras, but it was able to induce a small influx of Erk that could be measured with GFP-Erk2
Robinson-White et al., Hum Mol Genet 2003 : We investigated whether the PKA mediated inhibitory effect on ERK1/2 is affected in CNC cells that carry germline PRKAR1A mutations
Baldassa et al., Brain Res Mol Brain Res 2003 (MAP Kinase Signaling System) : Moreover, protein kinase A (PKA) activity is required for depolarization induced Rap1 activation and full Erk stimulation, but is not involved in that of Ras
Dalle et al., J Biol Chem 2004 : Inhibition of either cAMP dependent protein kinase (PKA) or MEK completely blocked ERK1/2 activation by glucagon ... We conclude that glucagon induced ERK1/2 activation is mediated by PKA and that an increase in [ Ca ( 2+ ) ] ( i ) is required for maximal ERK activation
Kawasaki et al., J Neurosci 2004 (Hyperalgesia) : The ERK activation produced by capsaicin is totally suppressed by inhibition of either protein kinase A (PKA) or PKC
Duca et al., Mol Pharmacol 2005 : The simultaneous inhibition of PKA and PI3K, by N- ( 2- ( p-bromocinnamylamino ) ethyl ) -5-isoquinolinesulfonamide ( H89 ) and 2- ( 4-morpholynil ) -8-phenyl-4H-1-bemzopyran-4-one ( LY294002 ), respectively, blocked MEK1/2 and ERK1/2 phosphorylation, as did lactose, an EBP antagonist
Deacon et al., Curr Biol 2005 : Finally, direct inhibition of PKA transiently activates ERK , demonstrating that ERK acts downstream of PKA
Subramaniam et al., J Neurosci 2005 : This indicates a selective role for PKA in ERK inhibition through c-Raf-Ser259 phosphorylation
Ji et al., Mol Cell Biol 2005 (Second Messenger Systems) : In NC cultures, high-level activation of cAMP signaling mediates protein kinase A (PKA) dependent Rap1-B-Raf-ERK1/2 activation, leading to cytoplasmic accumulation of phospho-Smad1, thus terminating bone morphogenetic protein 2 (BMP2) induced sympathoadrenal cell development
Lynch et al., J Biol Chem 2005 : Knockdown of PDE4D, but not PDE4B, amplifies isoprenaline stimulated phosphorylation of the beta2-adrenergic receptor ( beta2-AR ) by PKA and activation of extracellular signal regulated kinase ( ERK ) through G ( i )
Belcher et al., Endocrinology 2005 : Inhibition of Galphai signaling or protein kinase A (PKA) activity blocked the ability of ICI182,780 to rapidly stimulate ERK signaling
Mantovani et al., J Clin Endocrinol Metab 2005 (Adenoma...) : Moreover, in group 2, PKA blockade by the specific inhibitor PKI increased cyclin D1 expression ( 96 +/- 25 % over basal ) and ERK1/2 activity ( 116 +/- 28 % over basal )
Kiermayer et al., Mol Biol Cell 2005 (Pheochromocytoma) : The present study showed that specific stimulation of PKA triggered ERK1/2 activation that was considerably more transient than that observed upon simultaneous activation of both PKA and Epac ... Activation of Epac appeared to extend the duration of PKA dependent ERK1/2 activation and converted cAMP from a proliferative into an anti-proliferative, neurite outgrowth promoting signal
Houslay et al., Biochem Soc Trans 2005 : Beta-arrestin recruited phosphodiesterase-4 desensitizes the AKAP79/PKA mediated switching of beta2-adrenoceptor signalling to activation of ERK
Fassett et al., Mol Biol Cell 2006 : PKA inhibition also restored ERK activation, cyclin D1 expression and G1-S progression on collagen gel, but had no effect on cells adherent to collagen film
Calipel et al., J Biol Chem 2006 (Cell Transformation, Neoplastic...) : Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity, ERK1/2 activation, and cell proliferation in ( WT ) B-Raf cells, whereas it did not affect ( V600E ) B-Raf cells, demonstrating a key role of PKA in mediating ( WT ) B-Raf/ERK signaling for uveal melanoma cell growth ... This ruled out a role for Rap1 in the PKA mediated B-Raf/ERK activation in ( WT ) B-Raf cells
Gesty-Palmer et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Furthermore, stimulation of hPTH1R with PTH analogues, [ Trp1 ] PTHrp- ( 1-36 ) and [ d-Trp12, Tyr34 ] PTH- ( 7-34 ), selectively activated G ( s ) /PKA mediated ERK1/2 activation or G protein-independent/beta-arrestin dependent ERK1/2 activation, respectively
Jafri et al., J Biol Chem 2006 : While agonist dependent ERK1/2 activation by the NK1 receptor was independent of protein kinase A (PKA) or PKC activity, NK1-betaArr1 mediated ERK1/2 activation was completely inhibited when basal PKA and PKC activity were blocked
Laag et al., Int J Cancer 2006 (Adenocarcinoma...) : Using a cell line derived from a human pulmonary adenocarcinoma with Clara cell phenotype ( PACC ) and immortalized human small airway epithelial cells ( HPLD1 ), the putative cells of origin of this cancer type, our current studies have analyzed signaling initiated by binding of NNK to the beta 1-AR. NNK upregulated ERK1/2 and CREB/ATF-1 phosphorylation in a PKA dependent manner in both cell lines
Bolger et al., Biochem J 2006 : siRNA ( small interfering RNA ) -mediated knockdown of RACK1 in HEK-293 ( human embryonic kidney ) B2 cells increased beta-arrestin scaffolded PDE4D5 approx. 5-fold, increased PDE4D5 recruited to the beta2AR ( beta2-adrenergic receptor ) upon isoproterenol challenge approx. 4-fold and severely attenuated ( approx. 4-5 fold ) both isoproterenol stimulated PKA ( protein kinase A ) phosphorylation of the beta2AR and activation of ERK ( extracellular-signal regulated kinase )
Melling et al., J Mol Cell Cardiol 2006 (MAP Kinase Signaling System) : Inhibition of this PKA mediated increase in ERK1/2 phosphorylation through the simultaneous administration of an ERK1/2 inhibitor ( UB-1026 ; 0.25 mg/kg ) restored exercise induced hsp70 mRNA levels in PKA inhibited rats that previously demonstrated a suppressed response ( P < 0.05 )
Shimo et al., J Bone Miner Res 2006 (Bone Neoplasms...) : CCN2 was critically involved in osteolytic metastasis and was induced by PKA- and PKC dependent activation of ERK1/2 signaling by PTHrP
Charest et al., Cell Signal 2007 : Here we report that this activating pathway is independent of G alpha s, G alpha i, G alpha q or G betagamma and that the V2R mediated activation of G alpha s inhibits ERK1/2 activity in a cAMP/PKA dependent manner
Kara et al., Mol Endocrinol 2006 : Galpha ( s ) /PKA dependent ERK activation was rapid, transient, and blocked by H89 ( a PKA inhibitor ), but it was insensitive to small interfering RNA mediated depletion of beta-arrestins
Al-Wadei et al., Cancer Detect Prev 2006 (Adenocarcinoma...) : In BEAS-2B and NCI-H69 cells, the stimulation of cAMP/PKA reduced the phosphorylation of ERK1/2 and inhibited cell proliferation whereas phosphorylation of ERK1/2 and cell proliferation were increased in HPL1D and NCI-H322 cells
Xie et al., Mol Pharmacol 2007 (MAP Kinase Signaling System...) : Furthermore, PKA dependent Rap1 activation is required for both ERK1/2 activation and androgen independent AR activation in LNCaP cells upon VIP stimulation
Szatmari et al., J Neurosci 2007 : In cortical neurons, ERK1/2 activation by forskolin was protein kinase A (PKA) dependent but TrkB ( receptor tyrosine kinase B ) independent and was accompanied by the increased association between KSR1 and active ERK1/2
Barlow et al., Apoptosis 2008 : Application of H2O2 increased nuclear accumulation of PKA, and inhibition of PKA with H89 reduced oxidant mediated phosphorylation of both CREB and ERK1/2
Gerits et al., Cell Signal 2008 : The first- and best characterized interconnections are the PKA dependent inhibition of the MAPKs ERK1/2 mediated by RAF-1, and PKA induced activation of ERK1/2 interceded through B-RAF
Tang et al., Cell Signal 2008 : ERK ( 1/2 ) activation involves Gq/phospholipase C (PLC)/protein kinase C ( PKC ), Gs/adenylyl cyclase ( AC ) /cAMP/protein kinase A (PKA) and Gi cascades ; however, the Gq/PLC/PKC pathway, as well as PKA is not required for OX2R mediated p38 MAPK activation
Luke et al., Purinergic Signal 2008 : Inhibitors of protein kinase C ( PKC ), protein kinase A (PKA) , Ca ( 2+ ) /calmodulin dependent protein kinase II ( CaMKII ), and phosphoinositide-3 kinase (PI3K) had no effect on ATP mediated ERK1/2 phosphorylation
Lee et al., Biochemistry 2008 (MAP Kinase Signaling System) : Inhibiting PKA modestly attenuated ERK1/2 activation, while inhibition of Src family tyrosine kinases with PP2 abolished the response
Mao et al., Brain Res Bull 2009 (MAP Kinase Signaling System) : However, the increase in ERK1/2 phosphorylation was partially blocked by a protein kinase A (PKA) inhibitor
Nierth-Simpson et al., Endocrinology 2009 (Leiomyoma...) : cAMP-PKA signaling is rapidly activated only in UtSM cells with E2 and inhibits ERK1/2 activation and proliferation
Cao et al., J Neurosci 2009 (Pain) : Upstream, NMDA receptor, adenylyl cyclase ( AC ) and phosphokinase A (PKA) activators activated ERK in rACC slices
Qian et al., Glia 2009 : Furthermore, we found ERK inhibition, but not protein kinase A (PKA) inhibition , significantly abolished salmeterol induced superoxide production, p47(phox) translocation, and its ability to mediate neurotoxicity
Rodrigues et al., Mol Cell Endocrinol 2009 (MAP Kinase Signaling System) : Also, ERK1/2 activation is not significantly affected by protein kinase A (PKA) , protein kinase C ( PKC ) and protein kinase B or Akt ( Akt/PKB ) specific inhibitors
Almela et al., J Pharmacol Exp Ther 2009 (Substance Withdrawal Syndrome...) : The present findings demonstrate that the enhancement of ERK1/2 expression and the phosphorylation state of TH at Ser31 during morphine withdrawal are dependent on PKA and suggest cross-talk between PKA and ERK1/2 transduction pathway mediating morphine withdrawal induced activation ( phosphorylation ) of TH
Vuchak et al., Mol Pharmacol 2009 (MAP Kinase Signaling System) : By contrast, PKA activity was required for cAMP stimulated ERK phosphorylation and was sufficient to increase ERK phosphorylation in starved cells
Ding et al., Am J Physiol Cell Physiol 2009 : In contrast, in the absence of GPR30 expression in cultured VSMC, estradiol stimulated PKA activity and inhibited ERK phosphorylation
Spirli et al., Gastroenterology 2010 (Cysts...) : In Pkd2-defective LCECs, PKA dependent ERK1/2 signaling controls HIF-1alpha dependent VEGF secretion and VEGFR-2 signaling
Bidwell et al., Prostaglandins Other Lipid Mediat 2010 (Glioma...) : Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving PKA dependent inhibition of ERK
Hu et al., Acta Pharmacol Sin 2010 (Pancreatic Neoplasms) : Activation of beta-AR receptor transactivates epidermal growth factor receptor (EGFR) and then elicits Akt and ERK1/2 in a PKA dependent manner, which together up-regulate levels of HIF-1alpha and downstream target genes independently of oxygen level
Miyoshi et al., Mol Cell Endocrinol 2010 : Furthermore, in the presence of oocytes, the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin induced progesterone and cAMP, showing that endogenous FGF system is involved in activation of FSH induced cAMP-PKA signaling via ERK and SAPK/JNK
Roscioni et al., Br J Pharmacol 2011 : Activation of both Epac and PKA similarly prevented PDGF induced phenotype switching and PDGF induced activation of ERK
Santini et al., PloS one 2010 (Dyskinesias...) : We here studied, in the gold-standard non-human primate model of Parkinson 's disease, the changes in PKA dependent phosphorylation of DARPP-32 and GluR1 AMPA receptor, as well as in ERK and ribosomal protein S6 ( S6 ) phosphorylation, associated to acute and chronic administration of L-DOPA
Makarevich et al., Horm Metab Res 2010 : A PKA inhibitor, KT 5720 suppressed the expression of PKA and MAPK/ERK1,2 , the IGF-I release, and the ratio of PCNA positive cells in granulosa cells
Yen et al., J Biol Chem 2011 (MAP Kinase Signaling System) : PKA , PI3K, and ERK inhibitors abolished PGE2- and cAMP induced c-Fos and MMP-9 up-regulation, and ERK activation was required for the binding of activator protein 1 (AP-1) transcription factor to the MMP-9 promoter
Spirli et al., Hepatology 2012 (Calcium Signaling) : In Pkd2KO cells, ER-Ca ( 2+ ) depletion increases cAMP and PKA dependent ERK1/2 activation and both are inhibited by STIM1 inhibitors or by silencing of adenylyl cyclase type 6 ( AC6 )
Liu et al., Eur J Pharmacol 2012 (Calcium Signaling) : This negative effect was well correlated with increased cAMP levels via PKA activity and the subsequent inhibition of ERK ( p42/p44 ) phosphorylation to decrease superoxide anion production
Spirli et al., Hepatology 2012 (Cysts...) : Cyclic AMP/PKA dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib
Sun et al., Peptides 2012 : H89, a selective inhibitor of cyclic AMP dependent protein kinase A (PKA), inhibited the NPFF activated ERK pathway, indicating the involvement of PKA in the NPFF induced ERK activation
Havekes et al., J Neurosci 2012 : Furthermore, both hippocampal ß2-adrenergic receptor phosphorylation by PKA , and learning induced activation of ERK in the CA1 region of the hippocampus are attenuated in mice lacking gravin-a
Yao et al., J Biol Chem 1998 : Here we show that maximal sustained activation of ERK1 by NGF requires PKA ... Inhibitors of PKA partially blocked activation of ERK1 by NGF but had no effect on activation of ERK1 by EGF ... Inhibition of PKA also reduced the ability of NGF and cAMP, but not EGF, to activate the transcription factor Elk-1, reduced the induction of both immediate early and late genes after NGF treatment, and blocked the nuclear translocation of ERK1 induced by NGF
Moroo et al., Brain Res 1998 : Neither an inhibitor of PKA ( H89 ) nor inhibitors of PKC ( staurosporine and calphostin C ) had any effect on the ERK2 activation induced by 1 pM PACAP38
Impey et al., Neuron 1998 (Calcium Signaling) : Interestingly, the Ca2+ induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation
Putz et al., Cancer Res 1999 (Prostatic Neoplasms) : We have studied the effects of EGF, IGF-I, and the protein kinase A (PKA) activator forskolin on the activation of p42/ extracellular signal regulated kinase ( ERK ) 2, which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells