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CREB3 — LPA

Text-mined interactions from Literome

Lee et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : We found that LPA rapidly stimulated phosphorylation of CREB at Ser133 in a time- and dose dependent manner, as revealed by immunoblot analysis with a phospho-specific antibody recognizing CREB on Ser133 ... LPA induced phosphorylation of CREB was dependent on the activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 mitogen activated protein kinase ( p38 MAPK ) ... Inhibition of ERK1/2 with PD98059 and of p38 MAPK with SB203580 efficiently blocked LPA mediated phosphorylation of CREB ... The LPA induced CREB phosphorylation was abolished by H89, an inhibitor of mitogen- and stress activated protein kinase-1 ( MSK1 ) ... Together, these data suggest that LPA stimulates nuclear transcription factor CREB via mitogen activated protein kinase signaling components, ERK1/2, p38 MAPK, and MSK1 in Rat-2 fibroblast cells
Cechin et al., Neurochem Res 2005 (Glioma) : LPA induced transient ( 10 min ) phosphorylations of ERK 1/2, Akt and the transcription factor CREB ... The LPA induced phosphorylation of ERK 1/2 and CREB was blocked by inhibition of PI3K, PKC and MEK, but that of Akt was only inhibited by wortmannin, the PI3K inhibitor ... Inhibition of Rho kinase or NHE1 did not reduce the LPA induced phosphorylation of ERK, Akt or CREB
Rhee et al., Neuroreport 2006 : Moreover, LPA stimulated CREB phosphorylation, which was inhibited by not only H89 but also Rp-cAMP
Jang et al., Exp Mol Med 2006 : However, LPA dependent slope of luciferase increased more rapidly in senescent cells than in young cells, presumably due to an increase of LPA induced CREB phosphorylation
Lee et al., J Cell Biochem 2008 (MAP Kinase Signaling System) : Recently, we reported that LPA stimulates cAMP response element binding protein ( CREB ) through mitogen- and stress activated protein kinase-1 ( MSK1 ) ... To investigate the CREB mediated c-fos activation by LPA , various c-fos promoter-reporter constructs containing wild-type and mutated SRE and CRE were tested for their inducibility by LPA in transient transfection assays ... Chromatin immunoprecipitation assay revealed that LPA induced an increased binding of phosphorylated CREB and CREB binding protein (CBP) to the CRE region of the endogenous c-fos promoter
Kwon et al., Biochem Biophys Res Commun 2009 : Moreover, levels of c-fos mRNA and cyclin D1 protein were increased via LPA induced CREB phosphorylation
Kim et al., Mol Cells 2012 (Carcinoma, Embryonal...) : LPA induced phosphorylation of CREB was efficiently blocked by U0126 and H89, inhibitors of the MAP kinases ERK1/2 and mitogen- and stress activated protein kinase 1, respectively