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Liu et al., Eur J Pharmacol 2009
:
Furthermore,
l-THP inhibited the increased phosphorylation of
ERK and CREB in nucleus accumbens and hippocampus of rats
Siao et al., Molecules (Basel, Switzerland) 2011
(MAP Kinase Signaling System) :
To elucidate the signaling pathway of THP on PMN activation, we found
THP enhanced
ERK1/2 phosphorylation, reduced p38 MAP kinase phosphorylation, but had no effect on DNA binding of the five NF-kB family members in PMN
Kwon et al., J Cell Sci 2012
:
We also observed that in
THP-1 and PBMCs, AIMP1 induced TNF-a secretion, mediated by CD23,
involved activation of
ERK1/2