Caruso et al., Mol Cell Endocrinol 2012
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The effect of NDP-MSH on BDNF expression was abolished by the adenylate cyclase inhibitor SQ22536, and decreased by the PKA inhibitor Rp-cAMP
Braunger et al., Neurobiol Dis 2013
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We conclude that constitutive overexpression of Norrin protects photoreceptors from light damage, an effect that is mediated by Wnt/ß-catenin and EDN2 signaling and involves neurotrophic activities of BDNF