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CRP — LEP
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Menon et al., Clin Nephrol 2004
(Kidney Failure, Chronic) :
Multivariable analysis was used to evaluate the independent
effects of kidney function and
CRP on
leptin levels
Ble et al., Am J Cardiol 2005
:
It has been hypothesized that the hormone
leptin , released by fat cells, may
stimulate CRP production independent of cytokines ... In conclusion, these findings suggest that
leptin may directly
stimulate the production of
CRP independent of fat-cell produced cytokines in older adults
Chen et al., Nat Med 2006
(Body Weight) :
In vitro, human
CRP directly
inhibits the binding of
leptin to its receptors and blocks its ability to signal in cultured cells
Singh et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis) :
Leptin induces
C-reactive protein expression in vascular endothelial cells ... We tested the hypothesis that
leptin induces
CRP expression in human coronary artery endothelial cells ( HCAECs ) ...
Leptin induces
CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2
Dube et al., Peptides 2008
(Body Weight...) :
The elevated plasma
CRP and IL-6 levels seen in obese ob/ob mice receiving the control vector, regardless of the fat content of the diet, were markedly
suppressed by increased hypothalamic
leptin in both groups
Welsh et al., J Clin Endocrinol Metab 2010
(Inflammation) :
By contrast, adiposity allele score was associated with 1 ) an increase in BMI ( 1.2 kg/m ( 2 ) difference between extremes ; P for trend 0.002 ) ; 2 ) an increase in circulating
leptin ( 5.77 ng/ml difference between extremes ; P for trend 0.0027 ) ; and 3 )
increased CRP levels ( 1.24 mg/liter difference between extremes ; P for trend 0.002 )
Koethe et al., AIDS Res Hum Retroviruses 2012
(Acquired Immunodeficiency Syndrome...) :
Serum
leptin level
mediates the association of body composition and serum
C-reactive protein in HIV infected persons on antiretroviral therapy