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PRKCA — TNF

Text-mined interactions from Literome

Dieter et al., Cell Signal 2000 (Leukemia, Monocytic, Acute) : These results suggest that : ( 1 ) PKC-alpha but not PKC-beta is involved in the release of superoxide and PGE ( 2 ) ; ( 2 ) TNF-alpha release and the phagocytosis of latex particles are mediated by PKC-alpha, PKC-beta, and other PKC isoenzymes ; and ( 3 ) PKC-alpha and PKC-beta play antagonistic roles in the differentiation process of THP-1 cells
Ferro et al., Am J Physiol Lung Cell Mol Physiol 2000 : The TNF-alpha induced increase in PKC-alpha protein, PKC-alpha activity, and permeability was prevented by a 4-h pretreatment with PKC-alpha antisense oligonucleotide but not by the scrambled nonsense oligonucleotide
Lee et al., J Biol Chem 2000 : In L929 murine fibroblasts, TNF-alpha ( 0.5- 5 nm ) caused potent inhibition of PKC alpha activity and induced translocation of PKC alpha from the cytosol to the membrane ... Fumonisin B ( 1 ), an inhibitor of ceramide synthase, and glutathione, an inhibitor of neutral sphingomyelinase, both reversed the effect of TNF-alpha on PKC alpha activity, suggesting that ceramide production is necessary for the action of TNF-alpha ... Okadaic acid at 2 nm, a potent protein phosphatase inhibitor, blocked the effects of TNF-alpha on PKC alpha activity, but not on PKC alpha translocation, thus demonstrating that dephosphorylation and translocation are independent processes
Chang et al., Am J Physiol Gastrointest Liver Physiol 2001 : TNF-alpha also induced the translocation of PKC-alpha , -delta, and -epsilon from cytosol to the membrane fraction of the intestinal cells
Radeff et al., Exp Cell Res 2001 (Bone Resorption) : PTH, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta) induced translocation of PKC-alpha and -beta ( I ) to the plasma membrane in UMR-106 cells within 5 min
Aksoy et al., Eur J Immunol 2002 : Inhibition of LPS induced PKC activity using pseudosubstrate peptides specific for PKC isoforms established that PKC epsilon but not PKC alpha/beta was involved in the production of IL-12 and TNF-alpha
Satoh et al., Am J Physiol Gastrointest Liver Physiol 2004 : Both CCK-8 and TNF-alpha activated the novel isoforms PKC-delta and -epsilon and the atypical isoform PKC-zeta but not the conventional isoform PKC-alpha
Gopee et al., Cell Biol Toxicol 2004 : The aim of current study was to investigate the effect of PKCalpha activation by FB1 on NF-kappaB activation and subsequently on TNFalpha gene expression and caspase 3 induction in LLC-PK1 cells ... In summary, we hereby demonstrate that the FB1 activation of NF-kappaB and sequential induction of TNFalpha expression resulting in the subsequent increase in caspase 3 activity are all dependent on PKCalpha stimulation in LLC-PK1 cells
Cataisson et al., J Immunol 2005 (Inflammation) : Activation of PKCalpha increases the production of TNFalpha and the transcription of chemotactic factors ( MIP-2, KC, S100A8/A9 ), vascular endothelial growth factor, and GM-CSF in K5-PKCalpha keratinocytes
Cataisson et al., J Clin Invest 2006 (Dermatitis) : Inhibiting PKCalpha also reduced the basal and TNF-alpha- or TPA induced expression of CXCL8 in cultured psoriatic keratinocytes, suggesting that PKCalpha activity may contribute to psoriatic inflammation
Clayburgh et al., J Clin Invest 2006 (Diarrhea) : PKCalpha activation by TNF was responsible for NHE3 internalization, and pharmacological or genetic PKCalpha inhibition prevented NHE3 internalization, Na+ malabsorption, and diarrhea despite continued barrier dysfunction
Poole et al., J Allergy Clin Immunol 2007 (Inflammation) : Inhibition of PKCalpha and PKCepsilon reduced dust induced TNF-alpha secretion
Izumi et al., Hokkaido Igaku Zasshi 1995 : The effect of PKC alpha and beta 1 on the production of TNF-alpha and the augmentation of HIV-1 replication are inhibited by both anti-TNF-alpha antibody and staurosporine, a potent PKC inhibitor
Franz et al., Ann Surg Oncol 1996 (Carcinoma, Ductal, Breast...) : Concurrently, TNF-alpha induced the selective downregulation of PKC-alpha , whereas PKC-gamma levels increased
Ross et al., Endothelium : journal of endothelial cell research 1997 : These experiments revealed that : HUVEC clearly displayed a non-uniform basal membrane fraction distribution of PKC isoforms, with zeta ( 35.4 % ) greater than epsilon ( 30.6 % ) and both much greater than alpha ( 8.6 % ) ; Bradykinin caused significant translocation of PKC alpha with 15 min and 3 h of treatment but not 1 min ; TNF caused dramatic translocation of PKC alpha at 1 min treatment which subsided at 15 min and 3 h but remained significantly elevated ; and PMA caused dramatic translocation of alpha and epsilon but not zeta