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JAK3 — TNF

Text-mined interactions from Literome

Ait-Ali et al., Mol Endocrinol 2004 : Stimulatory effects of TNF-alpha on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor, and required activation of ERK 1/2 and p38, but not Janus kinase , MAPKs
Sareila et al., Int Immunopharmacol 2008 : The JAK3 inhibitor had no effect on COX-2 expression, and TNF-alpha production was slightly inhibited only at higher drug concentrations ( 30 microM )
Yarilina et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : Our findings demonstrate that JAK inhibitors suppress macrophage activation and attenuate TNF responses and further suggest that suppression of cytokine/chemokine production and innate immunity contribute to the therapeutic efficacy of JAK inhibitors
Nam et al., J Pept Sci 2012 : Inhibition of JAK ( STAT1/STAT5 kinase ) with AG490 markedly reduced the production of IL-6 and TNF-a in macrophages
Guo et al., J Immunol 1998 : Induction of Jak/STAT signaling by activation of the type 1 TNF receptor ... Phosphorylation of Jak proteins was also induced by human TNF , which selectively binds to TNFR1 on murine cells