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NFKB1 — TAB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Ninomiya-Tsuji et al., Nature 1999
:
Stimulation of
TAK1 causes activation of
NF-kappaB , which is blocked by dominant negative mutants of NIK, and an inactive TAK1 mutant prevents activation of NF-kappaB that is mediated by IL-1 but not by NIK
Irie et al., FEBS Lett 2000
:
A kinase negative mutant of
TAK1 inhibited the LPS induced
NF-kappaB activation both in a macrophage-like cell line, RAW 264.7, and in human embryonic kidney 293 cells expressing toll-like receptor 2 or 4
Mizukami et al., Mol Cell Biol 2002
(MAP Kinase Signaling System) :
Dominant negative forms of
TAK1 and TAB2
inhibit NF-kappaB activation induced by overexpression of RANK ... Furthermore, in murine monocyte RAW 264.7 cells, dominant negative forms of
TAK1 and TAB2
inhibit NF-kappaB activation induced by RANKL and endogenous TAK1 is activated in response to RANKL stimulation
Jiang et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Kinase inactive mutants of
TAK1 ( TAK1DN ) and PKR ( PKRDN )
inhibit poly ( dI.dC ) -induced TLR3 mediated
NFkappaB activation, suggesting that both of these kinases play important roles in this pathway
Rannou et al., Joint Bone Spine 2006
(Arthritis, Rheumatoid) :
When these cytokines bind to their membrane receptor, they set off signaling cascades, with
activation of TGFbeta activating kinase (
TAK-1 ), of
NF-kappaB by Ikappa-B kinase, of mitogen activated protein kinases ( MAP kinases ), and finally of activator protein-1 (AP-1)
Morlon et al., Hum Mol Genet 2005
(Ectodermal Dysplasia) :
TAB2, TRAF6 and
TAK1 are
involved in
NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd ... Moreover, we show that dominant negative forms of TAB2, TRAF6 and
TAK1 blocked the
NF-kappaB activation induced by Edaradd
Huang et al., Cell Death Differ 2006
:
Osteoclast differentiation
requires TAK1 and MKK6 for NFATc1 induction and
NF-kappaB transactivation by RANKL ...
TAK1-DN , MKK6-DN, and SB203580, but not MKK3-DN, also
suppressed RANKL stimulation of
NF-kappaB transcription activity in a manner dependent on p65 phosphorylation on Ser-536
Sethi et al., J Biol Chem 2006
:
NF-kappaB reporter activity
induced by TNFR1, TNF receptor associated death domain, TRAF2,
TAK1 , NF-kappaB inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection
Wan et al., Nat Immunol 2006
:
In mature thymocytes,
TAK1 was
required for interleukin 7-mediated survival and T cell receptor dependent activation of transcription factor
NF-kappaB and the kinase Jnk
Huangfu et al., J Biol Chem 2006
:
We found that TAO2 ( thousand-and-one amino acid kinase 2 ) associates with TAK1 and can inhibit
TAK1 mediated activation of
NF-kappaB but not of JNK
Sethi et al., Blood 2007
(Neoplasm Invasiveness...) :
Celastrol, a novel triterpene, potentiates TNF induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB regulated gene products and
TAK1 mediated
NF-kappaB activation ... Recent studies indicate that TNF induced IKK activation requires activation of TAK1, and we indeed found that celastrol inhibited the
TAK1 induced
NF-kappaB activation
Pandey et al., J Biol Chem 2007
:
As examined by DNA binding, we found that butein suppressed tumor necrosis factor (TNF) induced NF-kappaB activation in a dose- and time dependent manner ; suppressed the NF-kappaB activation induced by various inflammatory agents and carcinogens ; and inhibited the
NF-kappaB reporter activity
induced by TNFR1, TRADD, TRAF2, NIK,
TAK1/TAB1 , and IKK-beta ... As examined by DNA binding, we found that butein suppressed tumor necrosis factor (TNF) induced NF-kappaB activation in a dose- and time dependent manner ; suppressed the NF-kappaB activation induced by various inflammatory agents and carcinogens ; and inhibited the
NF-kappaB reporter activity
induced by TNFR1, TRADD, TRAF2, NIK,
TAK1/TAB1 , and IKK-beta
Suzuki et al., J Biol Chem 2007
(Cell Transformation, Viral...) :
Constitutive activation of
TAK1 by HTLV-1 tax dependent overexpression of TAB2
induces activation of JNK-ATF2 but not
IKK-NF-kappaB
Pandey et al., Blood 2007
(Neoplasm Metastasis) :
GA suppressed
NF-kappaB activation induced by various inflammatory agents and carcinogens and this, accompanied by the inhibition of
TAK1/TAB1 mediated IKK activation, inhibited IkappaBalpha phosphorylation and degradation, suppressed p65 phosphorylation and nuclear translocation, and finally abrogated NF-kappaB dependent reporter gene expression
Yang et al., J Biol Chem 2007
(Tuberculosis) :
We also demonstrate a
requirement for the E2-conjugating enzyme Ubc13, the E3 ubiquitin ligase Traf6, and the ubiquitin activated kinase
Tak1 in Nod2 mediated
NF-kappaB activation
Neil et al., Cancer Res 2008
(Disease Progression) :
Expression of a truncated
TAB1 mutant [ i.e., TAB1 ( 411 ) ]
reduced basal and TGF-beta mediated
NF-kappaB activation in NMuMG cells driven to undergo EMT by TGF-beta and in 4T1 cells stimulated by TGF-beta
Sethi et al., Mol Cancer Ther 2008
(Neoplasm Invasiveness...) :
Pinitol also suppressed the
NF-kappaB reporter activity
induced by tumor necrosis factor receptor (TNFR)-1, TNFR associated death domain, TNFR associated factor-2, transforming growth factor-beta activated kinase-1 ( TAK-1 )
/TAK1 binding protein-1 , and IkappaBalpha kinase but not that induced by p65
Tang et al., J Exp Med 2008
(Bone Marrow Diseases...) :
Activation of
TAK1 by proinflammatory cytokines and T and B cell receptors
induces the nuclear localization of
nuclear factor kappaB (NF-kappaB) and the activation of c-Jun N-terminal kinase (JNK)/AP1 and P38, which play important roles in mediating inflammation, immune responses, T and B cell activation, and epithelial cell survival
Yu et al., J Biol Chem 2008
:
Consistently, TAK1 mutant with alanine substitution of these two residues severely inhibits IL-1 induced NFkappaB and AP-1 activities, whereas
TAK1 mutant with replacement of these two sites with acidic residues slightly
enhances IL-1 induced
NFkappaB and AP-1 activities compared with the TAK1 wild-type
Zhou et al., World J Gastroenterol 2008
(Adenocarcinoma...) :
Viable LBG or LBG- ( s ) pretreatment attenuated the expression of TLR4,
inhibited the phosphorylation of
TAK1 and p38MAPK, prevented the activation of
NF-kappaB , and consequently blocked IL-8 production
Fraczek et al., J Biol Chem 2008
:
The kinase activity of IL-1 receptor associated kinase 4 is required for interleukin-1 receptor/toll-like receptor induced
TAK1 dependent
NFkappaB activation
Schuman et al., Blood 2009
:
The kinase
TAK1 is
essential for T-cell receptor ( TCR ) -mediated
nuclear factor kappaB (NF-kappaB) activation and T-cell development ... However, the
role of
TAK1 in B-cell receptor (BCR) mediated
NF-kappaB activation and B-cell development is not clear ... Thus,
TAK1 is
critical for B-cell maturation and BCR induced
NF-kappaB activation
Yamaguchi et al., Cell Biol Int 2009
(MAP Kinase Signaling System) :
JNK binding protein 1 regulates
NF-kappaB activation through TRAF2 and
TAK1
Henmi et al., Biochem J 2009
:
TAK1 ( transforming-growth-factor-beta activated kinase 1 ) mediates the IL-1 signalling pathway to NF-kappaB, and we observed that the
TAK1 induced
activation of
NF-kappaB was suppressed by PP2Ceta-2 expression
Lee et al., Biochim Biophys Acta 2009
:
DSCR1-1S also stimulated IL-1R mediated signaling pathways,
TAK1 activation,
NF-kappaB transactivation , and IL-8 production, all downstream consequences of IL-1R activation
Yamazaki et al., Science signaling 2009
:
Here, we showed that
TAK1 mediated activation of
NF-kappaB required the transient formation of a signaling complex that included tumor necrosis factor receptor associated factor 6 ( TRAF6 ), MEKK3, and TAK1
Cheng et al., J Biomed Mater Res A 2010
(Inflammation...) :
The critical
role for
TAK1 in p38MAPK and
NFkappaB activation was as well confirmed by the inhibition of p38MAPK and NFkappaB activity following 5Z-7-oxozeaenol, a selective inhibitor of TAK1
Lluis et al., PloS one 2010
:
Overexpression of IKK2-EE, a constitutive activator of NF-kappaB, protected TAK1-/- MEFs against TRAIL killing, suggesting that
TAK1 activation of
NF-kappaB is critical for the viability of cells treated with TRAIL
Srivastava et al., J Biol Chem 2010
:
Although both the
TAK1 and the CARMA1 binding sites in ADAP are
essential for IkappaB alpha phosphorylation and degradation and
NF-kappaB nuclear translocation, only the TAK1 binding site in ADAP is necessary for IKK phosphorylation