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IL6 — ST2

Text-mined interactions from Literome

Meisel et al., J Immunol 2001 : Exogenous IL-6 , IL-5, IL-1, and TNF-alpha enhanced the expression of T1/ST2 on Th2 cells, and IL-6 was by far most effective in this regard
Takezako et al., Biochem Biophys Res Commun 2006 : In this study, we demonstrated that a soluble secreted form of the ST2 gene product ( ST2 ) , a member of the interleukin-1 receptor family, suppressed the production of IL-6 in an LPS stimulated human monocytic leukemia cell line, THP-1 ... Immunofluorescence confocal microscopy revealed the binding of ST2 to the surface of the THP-1 cells, in which ST2 led to decreased binding of nuclear factor-kappaB to the IL-6 promoter ... These results demonstrated that ST2 negatively regulates LPS induced IL-6 production via the inhibition of IkappaB degradation in THP-1 cells
Rank et al., J Allergy Clin Immunol 2009 : Anti-ST2 antibody inhibited IL-6 production from IL-33 activated DCs by approximately 60 % ; anti-ST2 did not affect IL-6 production from LPS activated DCs
Talabot-Ayer et al., J Biol Chem 2009 : Finally, addition of full-length pro-IL-33 induced T1/ST2 dependent IL-6 secretion in mast cells