Gene interactions and pathways from curated databases and text-mining

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PARP1 — PDCD6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hassa et al., Frontiers in bioscience (Landmark edition) 2009 : This review briefly summarizes the recent findings, which support a crucial role of PARP1 in different programmed cell death and cell survival processes
Suzuki et al., Cancer Sci 2012 : We also observed that cytochrome c release and the cleavage of PARP by caspase-3 were suppressed by depletion of PDCD6
Saldeen et al., Mol Cell Endocrinol 1998 (Necrosis) : It is concluded that in insulin producing cells with a high mitotic rate, inhibition of ADP-ribosylation -- and consequently of auto-modification and release of PARP bound to DNA strand breaks -- leads to activation of programmed cell death