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IRF6 — JAK2

Text-mined interactions from Literome

Nomura et al., Toxicol Lett 1998 (Ischemic Attack, Transient) : LPS caused intranuclear translocation of NF-kappaB, and IFNgamma induced phosphorylation of Jak2 and Stat1, followed by the translocation of Stat1 into the nucleus
Cruz et al., Nitric Oxide 2001 : LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42
Okugawa et al., Am J Physiol Cell Physiol 2003 (Gram-Negative Bacterial Infections) : These results suggest that LPS induces tyrosine phosphorylation of JAK2 via TLR4 and that JAK2 regulates phosphorylation of JNK mainly through activation of PI3K
Severgnini et al., Am J Physiol Lung Cell Mol Physiol 2004 (Acute Disease...) : We also demonstrated that LPS activates both the STAT kinases, Src and JAK , in the lung with kinetics that are consistent with STAT activation
Kimura et al., Proc Natl Acad Sci U S A 2005 : We found that LPS directly activated Jak2 and Stat5, whereas SOCS-1 inhibited LPS induced Jak2 and Stat5 activation
Liu et al., Zhonghua Shao Shang Za Zhi 2005 : In addition, the cells were divided into normal control, LPS stimulation, JAK2 inhibition ( with AG490 treatment 2 hours before LPS stimulation ), STAT1 inhibition ( with fludarabine treatment 2 hours before LPS stimulation ) and STAT3 inhibition ( with rapamycin treatment 2 hours before LPS stimulation ) groups ... In addition, the cells were divided into normal control, LPS stimulation, JAK2 inhibition ( with AG490 treatment 2 hours before LPS stimulation ), STAT1 inhibition ( with fludarabine treatment 2 hours before LPS stimulation ) and STAT3 inhibition ( with rapamycin treatment 2 hours before LPS stimulation ) groups ... LPS could activate JAK2 , STAT1 and STAT3 within 2 hours, especially the activation of STAT3 appeared more quickly, peaking at 10 minutes after LPS stimulation ( 7.47 +/- 0.56 )
Wu et al., Br J Pharmacol 2009 : LPS + IFNgamma stimulated phosphorylation of ERK, JNK and Jak2 , and degradation of IkappaB, but only Jak2 phosphorylation was sensitive to tripterine ( 50-200 nM ) ... Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Zhu et al., Biol Pharm Bull 2013 (MAP Kinase Signaling System) : Mollugin significantly reduced the LPS mediated phosphorylation of Janus kinase (JAK) 2 , signal transducers and activators of transcription ( STAT ) 1 and STAT3