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CASP12 — EIF2S1

Text-mined interactions from Literome

Morley et al., FEBS Lett 2000 : Using a Jurkat cell line that is deficient in caspase-8 and resistant to anti-Fas induced apoptosis, we show that whilst the cleavage of eIF4GI is caspase-8 dependent, the enhancement of eIF2alpha phosphorylation does not require caspase-8 activity and occurs prior to the cleavage of eIF4GI
Saelens et al., J Biol Chem 2001 : Translation inhibition in apoptosis : caspase dependent PKR activation and eIF2-alpha phosphorylation
Aparna et al., Biochemistry 2003 : Consistent with these findings, it has been observed here that caspase activation has led to increased eIF2alpha phosphorylation, while caspase inhibition by z-VAD-fmk reduced eIF2alpha phosphorylation selectively in cells exposed to proapoptotic agents
Scheuner et al., J Biol Chem 2006 : TNFalpha treatment induced eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase PKR
Pushpanjali et al., Biochim Biophys Acta 2010 : PKC activation contributes to caspase mediated eIF2alpha phosphorylation and cell death ... While caspase activation is a cause and consequence of eIF2alpha phosphorylation, PKC activation that follows caspase activation further enhances caspase activation, eIF2alpha phosphorylation, and cell death in Sf9 cells
Zhang et al., Neurosci Lett 2010 : These results indicate that both the PERK/eIF2 alpha/ATF4 ISR and activation of caspase-12 may be involved in apoptosis of spinal cord astrocytes induced by OGSD/restoration
Cheng et al., Evidence-based complementary and alternative medicine : eCAM 2012 : Moreover, RQKL was able to reduce apoptotic process by reduction of caspase-3 expression, or restraint of eIF2a phosphorylation and caspase-12 activation