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MYC — PPP2CA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database C-MYC pathway:
Axin1/GSK3beta/PIN1/PP2A-B56alpha complex (AXIN1-GSK3B-PIN1-PPP2CA-PPP2R5A)
→
MYC/Max complex (MYC-MAX)
(modification, activates)
Sears et al., Genes Dev 2000, Gregory et al., J Biol Chem 2003, Yeh et al., Nat Cell Biol 2004, Arnold et al., Mol Cell Biol 2006, Arnold et al., EMBO J 2009
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yeh et al., Nat Cell Biol 2004
(Cell Transformation, Neoplastic...) :
Furthermore, the absence of Pin1 or inhibition of
PP2A stabilizes
c-Myc
Chen et al., Mol Cancer Res 2005
(Prostatic Neoplasms) :
Thus, the effects of Pim on
PP2A activity may
mediate the levels of
c-Myc and the phosphorylation of proteins needed for increased protein synthesis
Arnold et al., Mol Cell Biol 2006
:
PP2A mediates its effects on
c-Myc by dephosphorylating a conserved residue that normally stabilizes c-Myc, and in this way, PP2A enhances c-Myc ubiquitin mediated degradation
Guénin et al., Int J Oncol 2008
(Melanoma, Experimental) :
In untreated cells, okadaic acid, an antagonist of PP2A methylation,
inhibited PP2A activity, stimulated cell proliferation, increased Akt activation and
c-Myc expression
Arnold et al., Cancer Metastasis Rev 2008
:
This review will focus on the
role of
PP2A-B56alpha in regulating
c-Myc and will place this tumor suppressor activity of PP2A within the context of its other tumor suppressor functions
Mukhopadhyay et al., FASEB J 2009
:
Importantly, whereas down-regulation of I2PP2A enhanced
PP2A mediated
c-Myc degradation in response to ceramide, ectopic expression of wild-type I2PP2A but not of its K209D mutant protected this degradation in A549 cells
Mannava et al., Oncogene 2012
(Melanoma) :
Importantly,
PP2A-B56a overexpression
suppressed C-MYC in melanoma cells and induced OIS, whereas depletion of PP2A-B56a in normal human melanocytes upregulated C-MYC protein levels and suppressed BRAF ( V600E ) - and, less efficiently, NRAS ( Q61R ) -induced senescence