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Janssens et al., FEBS Lett 2003
:
MyD88 is an adapter protein that is involved in Toll-like receptor ( TLR ) - and interleukin-1 receptor (IL-1R) induced activation of nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK) Maloney et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
Here, we show that A52R does not inhibit TLR induced p38 or c-Jun amino N-terminal kinase (JNK) mitogen activating protein ( MAP ) kinase activation
Wang et al., Nat Immunol 2006
:
Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1 , transcriptional activators of innate immunity
Hu et al., J Leukoc Biol 2007
:
IFN-gamma suppression of TLR induced activation of AP-1 and downstream target genes challenges current concepts about the inflammatory role of AP-1 proteins in macrophage activation and is consistent with a role for AP-1 in the generation of noninflammatory osteoclasts
Zhu et al., Biochem J 2010
:
The mechanism was related to apoE suppression of TLR-agonist induced phosphorylation of JNK ( c-Jun N-terminal kinase ) and c-Jun Wen et al., J Exp Med 2010
(Peritonitis...) :
Rac1 activation is accompanied by JNK ( c-Jun N-terminal kinase ) and NF-?B activation, culminating in TLR induced binding of NF-?B and AP-1 to the promoters of inflammatory cytokines