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IRF3 — IRF6

Pathways - manually collected, often from reviews:

• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  

Text-mined interactions from Literome

Juang et al., J Biol Chem 1999 : Furthermore, LPS inhibited virus mediated phosphorylation of interferon regulatory factor (IRF)-3 and the consequent translocation of IRF-3 from cytoplasm to nucleus
Ohmori et al., J Leukoc Biol 2001 : Activation of these STAT1 containing transcription factors was mediated by the intermediate induction of type I IFNs, since the LPS induced IP-10, IRF-1 , and iNOS mRNA expression was markedly reduced in macrophages from IFN-alpha/betaR-/- mice and blocked by cotreatment with antibodies against type I IFN
Sakaguchi et al., Biochem Biophys Res Commun 2003 : Although much has been studied about the activation of the transcription factor IRF-3 and induction of IFN-beta gene by the LPS mediated TLR4 signaling, definitive evidence is missing about the actual role of IRF-3 in LPS responses in vitro and in vivo
Dang et al., J Immunol 2004 : In this study, we demonstrate that the LPS mediated activation of IRF3 and subsequent induction of chemokine genes or IRF3-responsive reporter constructs are inhibited after exposure of human or murine macrophages to the Bacillus anthracis toxin lethal factor
Dang et al., Shock 2004 (Inflammation...) : Here we show that the hydroxystilbene piceatannol inhibits the LPS mediated activation of IRF3 and subsequent ISG induction
Marson et al., J Biol Chem 2004 (Inflammation) : Inspection of the LPS induced activation state of several transcription factors known to play a prominent role in IFNbeta transcription reveals that, although NFkappaB, c-Jun, and ATF-2 activation appears normal, the LPS induced activation of IFNbeta regulatory factor 3 (IRF3) , as measured by DNA binding activity and association with the coactivator CBP, is inhibited in the OxLDL pre treated cells
Hemmi et al., J Exp Med 2004 (Virus Diseases) : Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA ( dsRNA ) induce phosphorylation of interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction ... Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA ( dsRNA ) induce phosphorylation of interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction ... Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA ( dsRNA ) induce phosphorylation of interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction
Takeuchi et al., J Endotoxin Res 2004 : Activation of IFN-regulatory factor (IRF) 3 in response to LPS and poly ( I:C ) was abolished in IKK-i/TBK1 doubly deficient cells
Pålsson-McDermott et al., Immunology 2004 : A later response to LPS makes use of TIR-domain containing adapter inducing interferon-beta ( TRIF ) and TRIF related adapter molecule (TRAM), and leads to the late activation of NF-kappaB and IRF3 , and to the induction of cytokines, chemokines, and other transcription factors
Nencioni et al., Blood 2006 : As a suitable mechanism for these effects, bortezomib was found to down-regulate MyD88, an essential adaptor for TLR signaling, and to relieve LPS induced activation of NF-kappaB, IRF-3 , and IRF-8 and of the MAP kinase pathway
Youn et al., Biochem Pharmacol 2006 : LPS induces the activation of NF-kappaB and IRF3 through MyD88- or TRIF dependent pathways ... Curcumin also inhibited LPS induced IRF3 activation
Youn et al., Biochem Pharmacol 2006 : EGCG inhibited the activation of IFN regulatory factor 3 (IRF3) induced by LPS , poly [ I:C ], or the overexpression of TRIF
Bibeau-Poirier et al., J Immunol 2006 (Virus Diseases) : In agreement with this observation, IRF-3 is recruited to Cullin1 following virus infection and overexpression of a dominant negative mutant of Cullin1 significantly inhibits the degradation of IRF-3 observed in infected cells
Aksoy et al., Blood 2007 : Although LPS induced IRF-3 nuclear translocation was observed both in adult and neonatal moDCs, IRF-3 DNA binding activity and association with the coactivator CREB binding protein (CBP) were decreased in neonatal as compared with adult moDCs
Ock et al., J Neurosci Res 2007 (Inflammation) : Hypoxia, however, differentially regulated MyD88 dependent and -independent pathways of TLR4 signaling : Hypoxia enhanced lipopolysaccharide (LPS) induced interferon regulatory factor-3 (IRF-3) activation and the subsequent expression of IFNbeta ( MyD88 independent pathway ), whereas it suppressed LPS induced NF-kappaB activation ( MyD88 dependent pathway )
Reimer et al., J Immunol 2007 (Listeriosis) : In contrast, vesicular stomatitis virus and LPS triggered IRF3 activation and signaling
Youn et al., Biochem Pharmacol 2008 : Our results showed that cinnamaldehyde suppressed the activation of NFkappaB and IRF3 induced by LPS , a TLR4 agonist, leading to the decreased expression of target genes such as COX-2 and IFNbeta in macrophages ( RAW264.7 )
Reimer et al., J Leukoc Biol 2008 : poly ( I:C ) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages
Youn et al., Int Immunopharmacol 2008 : Selenium inhibited IRF3 activation induced by poly [ I:C ], LPS or the overexpression of TRIF or TBK1
Abe et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation...) : Statins inhibited TLR4 mediated activation of interferon ( IFN ) regulatory factor ( IRF)3 by either lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
McCoy et al., J Biol Chem 2008 : IRF3 can be activated by Toll-like receptor 3 (TLR3) in response to the double stranded RNA mimic poly ( I-C ) and by TLR4 in response to lipopolysaccharide (LPS) ... It also inhibited increased phosphorylation of IRF3 in its N terminus in response to LPS and in its C terminus on Ser-396 in response to either poly ( I-C ) or LPS
Daffis et al., J Virol 2008 (Viremia...) : In cell culture, many RNA viruses trigger IFN responses through the binding of RNA recognition molecules ( RIG-I, MDA5, and TLR-3 ) and induction of interferon regulatory factor IRF-3 dependent gene transcription
Park et al., Biosci Biotechnol Biochem 2009 : Our goal was to identify the molecular target of 6-shogaol in the TRIF dependent pathway of TLRs. 6-Shogaol inhibited the activation of interferon-regulatory factor 3 (IRF3) induced by lipopolysaccharide (LPS) and by polyriboinosinic polyribocytidylic acid ( poly [ I:C ] ), overexpression of TRIF, TANK binding kinase1 (TBK1), and IRF3
Sweeney et al., J Immunol 2010 (Arthritis, Rheumatoid) : IRF3 regulates IFN stimulated response element ( ISRE ) promoter activity as well as IFN-beta, IRF5 , IRF7, RANTES, IFN-inducible protein-10, MCP-1, and MIP1alpha gene expression in response to poly ( I-C )
Into et al., Cell Immunol 2010 (Bacterial Infections...) : LL-37 potently suppressed LPS induced gene expression of IL6, IL8 and CXCL10 and intracellular signaling events, degradation of IRAK-1 and IkappaBalpha and phosphorylation of p38 MAPK and IRF3 , indicating that the LPS neutralizing activity is also exerted in HGFs. LL-37 also suppressed the expression of IL6, IL8 and CXCL10 induced by the TLR3 ligand poly ( I:C )
Ogasawara et al., Journal of clinical biochemistry and nutrition 2011 : Rebamipide reduced the expression of TBK1, IRF3 and IRF7 mRNA induced by LPS/dsRNA , but not of NF-?B mRNA in colonic epithelial cells
He et al., Eur J Immunol 2011 (Listeriosis...) : Conversely, overexpression of CLIC4 enhanced LPS mediated IRF3
Sugiyama et al., Mol Immunol 2012 : Further, we examined the effect of 2-AP on LPS induced IRF-3 activation by immunoblotting ... While 2-AP did not affect LPS induced phosphorylation of IRF-3 , nuclear translocation of IRF-3 was inhibited
Ke et al., Hepatology 2013 (Disease Models, Animal...) : In contrast, knockdown of ß-catenin increased PTEN/TLR4 ( Toll-like receptor 4 ), interferon regulatory factor-3 (IRF3), nuclear factor kappa B ( NF-?B ) activity, and proinflammatory cytokine programs in response to LPS stimulation
Etoh et al., Eur J Pharmacol 2013 : However, it showed no effect on LPS induced nuclear translocation of interferon regulatory factor (IRF)-3 , a MyD88 independent signaling molecule
Kim et al., Br J Pharmacol 2013 : The inhibitory effect on LPS induced IRF3 activation by CAPE was not observed when 293T cells were reconstituted with MD2 ( C133S ) mutant
Faure et al., J Biol Chem 1999 : The decrease of LPS/IFN-gamma induced IRF-1 promoter activity, IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds