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AHSA1 — MMP9
Text-mined interactions from Literome
Simon et al., Exp Cell Res 2001
(Neoplasm Invasiveness...) :
Considering that TPA is a potent activator of AP-1, we hypothesized that this transcription factor might also be required for
p38 pathway
dependent MMP-9 regulation
Lee et al., J Biomed Sci 2003
(Liver Cirrhosis) :
Differential
role of
p38 in IL-1alpha induction of
MMP-9 and MMP-13 in an established liver myofibroblast cell line
Wang et al., Shock 2005
(Endotoxemia...) :
The enhanced
MMP-9 levels induced by peptidoglycan was
attenuated by inhibitors of
p38 mitogen activated protein kinases ( MAPK ), ( SB202190, 25 microM ) and ERK1/2 ( PD98059, 25 microM ) and inhibitors of Src Tyrosine kinase ( PP2, 5 microM ) and PI3-K ( LY294002, 25 microM )
Hsieh et al., J Rheumatol 2007
(Osteoarthritis, Knee) :
Enzyme linked immunosorbent assay and gelatin zymography were used to investigate the
effects of ERK 1/2 inhibitor U0126, JNK and
p38 inhibitor SB203580, and PI3K inhibitor LY294002 on the secretion of u-PA, PAI-1, MMP-2, and
MMP-9 in early osteoarthritic tissue cultures, with or without interleukin 1alpha (IL-1alpha) and lipopolysaccharide (LPS) induction
Tsai et al., J Cell Biochem 2008
:
Cilostazol significantly inhibited LPS induced activation of p38, JNK, and nuclear factor-kappaB, and the respective inhibitors of
p38 and JNK greatly
reduced the level of LPS induced MCP-1 and
MMP-9 , suggesting the involvement of the p38 and JNK pathways
Zhang et al., J Surg Res 2011
(Aortic Aneurysm, Abdominal...) :
Inhibition of ERK ( UO126 ) or
p38 ( SB203580 ), but not PI3K ( LY294002 or wortmannin ),
blocked AGE induced
MMP-9 expression