Gene interactions and pathways from curated databases and text-mining

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AHSA1 — MMP9

Text-mined interactions from Literome

Simon et al., Exp Cell Res 2001 (Neoplasm Invasiveness...) : Considering that TPA is a potent activator of AP-1, we hypothesized that this transcription factor might also be required for p38 pathway dependent MMP-9 regulation
Lee et al., J Biomed Sci 2003 (Liver Cirrhosis) : Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line
Wang et al., Shock 2005 (Endotoxemia...) : The enhanced MMP-9 levels induced by peptidoglycan was attenuated by inhibitors of p38 mitogen activated protein kinases ( MAPK ), ( SB202190, 25 microM ) and ERK1/2 ( PD98059, 25 microM ) and inhibitors of Src Tyrosine kinase ( PP2, 5 microM ) and PI3-K ( LY294002, 25 microM )
Hsieh et al., J Rheumatol 2007 (Osteoarthritis, Knee) : Enzyme linked immunosorbent assay and gelatin zymography were used to investigate the effects of ERK 1/2 inhibitor U0126, JNK and p38 inhibitor SB203580, and PI3K inhibitor LY294002 on the secretion of u-PA, PAI-1, MMP-2, and MMP-9 in early osteoarthritic tissue cultures, with or without interleukin 1alpha (IL-1alpha) and lipopolysaccharide (LPS) induction
Tsai et al., J Cell Biochem 2008 : Cilostazol significantly inhibited LPS induced activation of p38, JNK, and nuclear factor-kappaB, and the respective inhibitors of p38 and JNK greatly reduced the level of LPS induced MCP-1 and MMP-9 , suggesting the involvement of the p38 and JNK pathways
Zhang et al., J Surg Res 2011 (Aortic Aneurysm, Abdominal...) : Inhibition of ERK ( UO126 ) or p38 ( SB203580 ), but not PI3K ( LY294002 or wortmannin ), blocked AGE induced MMP-9 expression