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DNMT1 — UHRF1

Pathways - manually collected, often from reviews:

• Reactome Reaction: UHRF1 → DNMT1 (reaction) Pradhan et al., J Biol Chem 1999, Bostick et al., Science 2007, Ooi et al., Curr Biol 2008, Song et al., Science 2011, Zhang et al., Cell Res 2011, Hervouet et al., Cell division 2012*, Bashtrykov et al., J Biol Chem 2014
• Reactome Reaction: UHRF1 → DNMT1 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: UHRF1 — DNMT1 (physical association, affinity chromatography technology) Hervouet et al., PloS one 2010*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (physical association, affinity chromatography technology) Zhang et al., Cell Res 2011
• IRef Biogrid Interaction: UHRF1 — DNMT1 (direct interaction, pull down) Achour et al., Oncogene 2008*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (direct interaction, enzymatic study) Qin et al., J Cell Biochem 2011*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (colocalization, imaging technique) Jin et al., Breast Cancer Res Treat 2010*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (direct interaction, two hybrid) Achour et al., Oncogene 2008*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (physical association, affinity chromatography technology) Felle et al., Nucleic Acids Res 2011*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (physical association, affinity chromatography technology) Du et al., Science signaling 2010*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (physical association, affinity chromatography technology) Bostick et al., Science 2007
• IRef Biogrid Interaction: UHRF1 — DNMT1 (direct interaction, pull down) Bostick et al., Science 2007
• IRef Biogrid Interaction: UHRF1 — DNMT1 (direct interaction, pull down) Felle et al., Nucleic Acids Res 2011*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (physical association, affinity chromatography technology) Achour et al., Biochem Biophys Res Commun 2009*
• IRef Biogrid Interaction: UHRF1 — DNMT1 (physical association, affinity chromatography technology) Achour et al., Oncogene 2008*
• IRef Intact Interaction: UHRF1 — DNMT1 (colocalization, confocal microscopy) Achour et al., Oncogene 2008*
• IRef Intact Interaction: UHRF1 — DNMT1 (physical association, two hybrid) Achour et al., Oncogene 2008*
• IRef Intact Interaction: UHRF1 — DNMT1 (physical association, pull down) Achour et al., Oncogene 2008*
• IRef Intact Interaction: UHRF1 — DNMT1 (physical association, anti tag coimmunoprecipitation) Meilinger et al., EMBO Rep 2009*
• IRef Intact Interaction: Complex of DNMT1-UHRF1-DNMT3A (physical association, anti tag coimmunoprecipitation) Meilinger et al., EMBO Rep 2009*
• IRef Intact Interaction: Complex of 25 proteins (association, anti bait coimmunoprecipitation) Achour et al., Oncogene 2008*

Text-mined interactions from Literome

Arita et al., Nature 2008 : The protein UHRF1 ( also known as Np95 and ICBP90 ) recognizes hemi-methylation sites via a SET and RING associated ( SRA ) domain and directs Dnmt1 to these sites
Felle et al., Nucleic Acids Res 2011 : The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
Zhang et al., Cell Res 2011 : Recent studies demonstrate that UHRF1 is required for DNA methylation maintenance by targeting DNMT1 to DNA replication foci, presumably through its unique hemi methylated DNA binding activity and interaction with DNMT1